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Impact of baseline ...
Impact of baseline severity of aortic valve stenosis on effect of intensive lipid lowering therapy (from the SEAS study)
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Gerdts, Eva (author)
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Rossebø, Anne Bjørhovde (author)
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Pedersen, Terje Rolf (author)
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- Boman, Kurt (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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Brudi, Philippe (author)
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Chambers, John Boyd (author)
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Egstrup, Kenneth (author)
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Gohlke-Bärwolf, Christa (author)
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Holme, Ingar (author)
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Kesäniemi, Y Antero (author)
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Malbecq, William (author)
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Nienaber, Christoph (author)
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Ray, Simon (author)
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Skjærpe, Terje (author)
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Wachtell, Kristian (author)
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- Willenheimer, Ronnie (author)
- Lund University,Lunds universitet,Kardiologiska klinikens forskargrupp,Forskargrupper vid Lunds universitet,Cardiology Research Group,Lund University Research Groups
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(creator_code:org_t)
- Elsevier, 2010
- 2010
- English.
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In: American Journal of Cardiology. - : Elsevier. - 0002-9149 .- 1879-1913. ; 106:11, s. 1634-1639
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Retrospective studies have suggested a beneficial effect of lipid-lowering treatment on the progression of aortic stenosis (AS) in milder stages of the disease. In the randomized, placebo-controlled Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study, 4.3 years of combined treatment with simvastatin 40 mg and ezetimibe 10 mg did not reduce aortic valve events (AVEs), while ischemic cardiovascular events (ICEs) were significantly reduced in the overall study population. However, the impact of baseline AS severity on treatment effect has not been reported. Baseline and outcomes data in 1,763 SEAS patients (mean age 67 years, 39% women) were used. The study population was divided into tertiles of baseline peak aortic jet velocity (tertile 1: <= 2.8 m/s; tertile 2: >2.8 to 3.3 m/s; tertile 3: >3.3 m/s). Treatment effect and interaction were tested in Cox regression analyses. The rates of AVEs and ICEs increased with increasing baseline severity of AS. In Cox regression analyses, higher baseline peak aortic jet velocity predicted higher rates of AVEs and ICEs in all tertiles (all p values <0.05) and in the total study population (p <0.001). Simvastatin-ezetimibe treatment was not associated with a statistically significant reduction in AVEs in any individual tertile. A significant quantitative interaction between the severity of AS and simvastatin-ezetimibe treatment effect was demonstrated for ICEs (p <0.05) but not for AVEs (p = 0.10). In conclusion, the SEAS study results demonstrate a strong relation between baseline the severity of AS and the rate of cardiovascular events but no significant effect of lipid-lowering treatment on AVEs, even in the group with the mildest AS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- A reductase inhibitors
- progression
- association
- disease
- Rosuvastatin
- Simvastatin
- guidelines
- Ezetimibe
- sclerosis
- statins
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Gerdts, Eva
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Rossebø, Anne Bj ...
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Pedersen, Terje ...
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Boman, Kurt
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Brudi, Philippe
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Chambers, John B ...
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show more...
-
Egstrup, Kenneth
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Gohlke-Bärwolf, ...
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Holme, Ingar
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Kesäniemi, Y Ant ...
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Malbecq, William
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Nienaber, Christ ...
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Ray, Simon
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Skjærpe, Terje
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Wachtell, Kristi ...
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Willenheimer, Ro ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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American Journal ...
- By the university
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Umeå University
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Lund University