Design, synthesis and evaluation of novel polypharmacological antichlamydial agents

• Discovery of new polypharmacological antibacterial agents with multiple modes of actions can be an alternative to combination therapy and also a possibility to slow development of antibiotic resistance. In support to this hypothesis, we synthesized 16 compounds by combining the pharmacophores of Chlamydia trachomatis inhibitors and inhibitors of type III secretion (T3S) in gram-negative bacteria. In this study we have developed salicylidene acylhydrazide sulfonamides (11c & 11d) as new antichlamydial agents that also inhibit T3S in Yersinia pseudotuberculosis.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)

Keyword

Sulfonamides

Acylhydrazones

Heck coupling

Cyanation

Urea derivatives

Thiourea derivatives

lamydia trachomatis

Chlamydia pneumoniae

Type III secretion system

Antibiotic development

Publication and Content Type

ref (subject category)

art (subject category)