Role of monoamine oxidase A genotype and psychosocial factors in male adolescent criminal activity

Nilsson, Kent W.Uppsala universitet,Centrum för klinisk forskning, Västerås (author)

Uppsala Univ, Clin Res Ctr, Cent Hosp Vasteras, S-72189 Vasteras, Sweden. Uppsala Univ, Dept Neurosci, Pharmacol Unit, S-72189 Uppsala, Sweden.Elsevier,2006
printrdacarrier

BACKGROUND: A number of important sociological, psychological, and biological predictors of adolescent criminal behavior have been identified during the most recent decades. The aim of this study was to replicate recent findings that interactions between a polymorphism in the monoamine oxidase A (MAO-A) gene promoter region and psychosocial factors might predict male adolescent criminal activity.METHODS: A cross-sectional study with a randomized sample from the total population of 16- and 19-year-olds from the county of Västmanland, Sweden. Eighty-one male adolescents, who volunteered to participate, were randomly selected from groups representing different degrees of deviant risk behavior.RESULTS: The present study strongly supports the notion that carrying the 3-repeat allele of the MAO-A-gene promoter increases the risk of male adolescent criminal behavior, when interacting with psychosocial factors. No effects at all of the MAO-A genotype on adolescent criminal activity were found when MAO-A genotype was considered alone (i.e., without its psychosocial context). The explained variance of the bio-psychosocial model (controlling for MAO-A) in this study exceeded the psychosocial model by 12%.CONCLUSIONS: The findings support the notion that genotype and psychosocial factors interact to precipitate male adolescent criminal behavior.

Sjöberg, Rickard L.Uppsala universitet,Centrum för klinisk forskning, Västerås(Swepub:uu)leiflind (author)
Damberg, MattiasUppsala universitet,Farmakologi (author)
Leppert, JerzyUppsala universitet,Centrum för klinisk forskning, Västerås(Swepub:uu)jelep103 (author)
Öhrvik, JohnUppsala universitet,Karolinska Institutet,Centrum för klinisk forskning, Västerås (author)
Alm, Per OlofUppsala universitet,Centrum för klinisk forskning, Västerås (author)
Lindström, LeifCentre for Clinical Research, Uppsala University, Central Hospital Västerås, Västerås, Sweden (author)
Oreland, LarsUppsala universitet,Farmakologi(Swepub:uu)larsore (author)
Uppsala universitetCentrum för klinisk forskning, Västerås (creator_code:org_t)

In:Biological PsychiatryUppsala Univ, Clin Res Ctr, Cent Hosp Vasteras, S-72189 Vasteras, Sweden. Uppsala Univ, Dept Neurosci, Pharmacol Unit, S-72189 Uppsala, Sweden. : Elsevier59:2, s. 121-1270006-32231873-2402

By the author/editor: Nilsson, Kent W.; Sjöberg, Rickard ...; Damberg, Mattias; Leppert, Jerzy; Öhrvik, John; Alm, Per Olof; show more...; Lindström, Leif; Oreland, Lars; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

By the university: Umeå University; Mälardalen University; Karolinska Institutet; Uppsala University

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.