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Heterogeneous cytog...
Heterogeneous cytogenetic subgroups and outcomes in childhood acute megakaryoblastic leukemia : a retrospective international study
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Inaba, Hiroto (author)
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Zhou, Yinmei (author)
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Abla, Oussama (author)
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Adachi, Souichi (author)
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Auvrignon, Anne (author)
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Beverloo, H. Berna (author)
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de Bont, Eveline (author)
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Chang, Tai-Tsung (author)
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Creutzig, Ursula (author)
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Dworzak, Michael (author)
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Elitzur, Sarah (author)
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Fynn, Alcira (author)
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- Forestier, Erik (author)
- Umeå universitet,Medicinsk och klinisk genetik,Nordic Society for Pediatric Hematology and Oncology, Stockholm, Sweden
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Hasle, Henrik (author)
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Liang, Der-Cherng (author)
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Lee, Vincent (author)
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Locatelli, Franco (author)
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Masetti, Riccardo (author)
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De Moerloose, Barbara (author)
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Reinhardt, Dirk (author)
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Rodriguez, Laura (author)
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Van Roy, Nadine (author)
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Shen, Shuhong (author)
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Taga, Takashi (author)
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Tomizawa, Daisuke (author)
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Yeoh, Allen E. J. (author)
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Zimmermann, Martin (author)
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Raimondi, Susana C. (author)
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(creator_code:org_t)
- American Society of Hematology, 2015
- 2015
- English.
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In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 126:13, s. 1575-1584
- Related links:
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https://ashpublicati...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Comprehensive clinical studies of patients with acute megakaryoblastic leukemia (AMKL) are lacking. We performed an international retrospective study on 490 patients (age <= 18 years) with non-Down syndrome de novo AMKL diagnosed from 1989 to 2009. Patients with AMKL (median age 1.53 years) comprised 7.8% of pediatric AML. Five-year event-free (EFS) and overall survival (OS) were 43.7% +/- 2.7% and 49.0% +/- 2.7%, respectively. Patients diagnosed in 2000 to 2009 were treated with higher cytarabine doses and had better EFS (P = .037) and OS (P = .003) than those diagnosed in 1989 to 1999. Transplantation in first remission did not improve survival. Cytogenetic data were available for 372 (75.9%) patients: hypodiploid (n = 18, 4.8%), normal karyotype (n = 49, 13.2%), pseudodiploid (n = 119, 32.0%), 47 to 50 chromosomes (n = 142, 38.2%), and >50 chromosomes (n=44, 11.8%). Chromosome gain occurred in 195 of 372 (52.4%) patients: +21 (n = 106, 28.5%), +19 (n = 93, 25.0%), +8 (n = 77, 20.7%). Losses occurred in 65 patients (17.5%): -7 (n = 13, 3.5%). Common structural chromosomal aberrations were t(1; 22)(p13; q13) (n = 51, 13.7%) and 11q23 rearrangements (n = 38, 10.2%); t(9; 11)(p22; q23) occurred in 21 patients. On the basis of frequency and prognosis, AMKL can be classified to 3 risk groups: good risk-7p abnormalities; poor risk-normal karyotypes, -7, 9p abnormalities including t(9;11)(p22;q23)/MLL-MLLT3, -13/13q-, and -15; and intermediate risk-others including t(1;22)(p13;q13)/OTT-MAL (RBM15-MKL1) and 11q23/MLL except t(9;11). Risk-based innovative therapy is needed to improve patient outcomes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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- ref (subject category)
- art (subject category)
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Blood
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- By the author/editor
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Inaba, Hiroto
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Zhou, Yinmei
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Abla, Oussama
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Adachi, Souichi
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Auvrignon, Anne
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Beverloo, H. Ber ...
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show more...
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de Bont, Eveline
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Chang, Tai-Tsung
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Creutzig, Ursula
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Dworzak, Michael
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Elitzur, Sarah
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Fynn, Alcira
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Forestier, Erik
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Hasle, Henrik
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Liang, Der-Chern ...
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Lee, Vincent
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Locatelli, Franc ...
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Masetti, Riccard ...
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De Moerloose, Ba ...
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Reinhardt, Dirk
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Rodriguez, Laura
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Van Roy, Nadine
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Shen, Shuhong
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Taga, Takashi
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Tomizawa, Daisuk ...
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Yeoh, Allen E. J ...
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Zimmermann, Mart ...
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Raimondi, Susana ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Blood
- By the university
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Umeå University