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- Wang, PanKey Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, China; Clinical Laboratory, The First Hospital of Yulin City, Yulin, China (author)
Genome-wide study identifies the regulatory glycosyltransferase genes networks and signaling pathways from Keshan disease
- Article/chapterEnglish2014
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- David Publishing Company,2014
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- LIBRIS-ID:oai:DiVA.org:umu-111603
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-111603URI
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- Language:English
- Summary in:English
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- KD (Keshan disease) is an endemic cardiomyopathy occurring only in China. Its pathogenesis is unclear till now. In the study, gene expression profiles of the PBMC (peripheral blood mononuclear cell) derived respectively from KD patients and healthy in KD areas were compared. Total RNA was isolated, amplified, labeled and hybridized to Agilent 4 × 44 K Whole Human Genome Oligonucleotide Microarray. Significant canonical pathways were analyzed by IPA (ingenuity pathway analysis) to identify differently expressed genes and pathways involved in the cardiovascular system development and function. Quantitative RT-PCR was applied tofurther validate our microarray results. Eighty-three up-regulated (ratios ≥ 2.0) and nine down-regulated glycosyltransferase genes (ratios ≤ 0.5) in PBMC in KD patients were detected by significance analysis of microarrays. Two significant canonical pathways from glycosyltransferase gene expression profiles were screened by IPA. The results of qRT-PCR show that four up-regulated (BMP1/7/10 and FGF18) and one down-regulated (BMP2) genes are consistent with those in microarray experiment, confirming the validity of the microarray data. Based on the results of the study, it is suggested that bone morphogenetic proteins and fibroblast growth factors might play an important role in the pathogenesis of KD. This further helps us to understand the pathogenesis of KD, as well as dilated cardiomyopathy
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
- NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
- eshan disease
- glycosyltransferase gene
- signaling pathway
- bone morphogeneti c protein
- fibroblast growth factor
- biokemi
- Biochemistry
- Cardiology
- kardiologi
- cell research
- cellforskning
Added entries (persons, corporate bodies, meetings, titles ...)
- Tan, WuhongKey Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, China (author)
- Qu, Chengjuan,1967-Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group(Swepub:umu)chqu0007 (author)
- Zhang, FengKey Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, China (author)
- He, ShulanKey Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, China (author)
- Zheng, JingjingKey Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, China (author)
- Shan, HuDepartment of Respiratory Medicine, The Second Affiliated Hospital, Xi’an Jiaotong University Health Science Center, Xi’an, China (author)
- Su, XiaohuiKey Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, China (author)
- Wang, BinKey Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, China (author)
- Guo, XiongKey Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, China (author)
- Key Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, China; Clinical Laboratory, The First Hospital of Yulin City, Yulin, ChinaKey Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, China (creator_code:org_t)
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- In:Journal of Health Science: David Publishing Company2:4, s. 165-173
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