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Genome-wide study i...
Genome-wide study identifies the regulatory glycosyltransferase genes networks and signaling pathways from Keshan disease
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- Wang, Pan (author)
- Key Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, China; Clinical Laboratory, The First Hospital of Yulin City, Yulin, China
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- Tan, Wuhong (author)
- Key Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, China
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- Qu, Chengjuan, 1967- (author)
- Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group
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- Zhang, Feng (author)
- Key Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, China
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- He, Shulan (author)
- Key Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, China
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- Zheng, Jingjing (author)
- Key Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, China
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- Shan, Hu (author)
- Department of Respiratory Medicine, The Second Affiliated Hospital, Xi’an Jiaotong University Health Science Center, Xi’an, China
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- Su, Xiaohui (author)
- Key Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, China
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- Wang, Bin (author)
- Key Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, China
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- Guo, Xiong (author)
- Key Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, China
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(creator_code:org_t)
- David Publishing Company, 2014
- 2014
- English.
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In: Journal of Health Science. - : David Publishing Company. ; 2:4, s. 165-173
- Related links:
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https://urn.kb.se/re...
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Abstract
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- KD (Keshan disease) is an endemic cardiomyopathy occurring only in China. Its pathogenesis is unclear till now. In the study, gene expression profiles of the PBMC (peripheral blood mononuclear cell) derived respectively from KD patients and healthy in KD areas were compared. Total RNA was isolated, amplified, labeled and hybridized to Agilent 4 × 44 K Whole Human Genome Oligonucleotide Microarray. Significant canonical pathways were analyzed by IPA (ingenuity pathway analysis) to identify differently expressed genes and pathways involved in the cardiovascular system development and function. Quantitative RT-PCR was applied tofurther validate our microarray results. Eighty-three up-regulated (ratios ≥ 2.0) and nine down-regulated glycosyltransferase genes (ratios ≤ 0.5) in PBMC in KD patients were detected by significance analysis of microarrays. Two significant canonical pathways from glycosyltransferase gene expression profiles were screened by IPA. The results of qRT-PCR show that four up-regulated (BMP1/7/10 and FGF18) and one down-regulated (BMP2) genes are consistent with those in microarray experiment, confirming the validity of the microarray data. Based on the results of the study, it is suggested that bone morphogenetic proteins and fibroblast growth factors might play an important role in the pathogenesis of KD. This further helps us to understand the pathogenesis of KD, as well as dilated cardiomyopathy
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- eshan disease
- glycosyltransferase gene
- signaling pathway
- bone morphogeneti c protein
- fibroblast growth factor
- biokemi
- Biochemistry
- Cardiology
- kardiologi
- cell research
- cellforskning
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Wang, Pan
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Tan, Wuhong
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Qu, Chengjuan, 1 ...
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Zhang, Feng
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He, Shulan
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Zheng, Jingjing
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show more...
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Shan, Hu
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Su, Xiaohui
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Wang, Bin
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Guo, Xiong
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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Umeå University