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Physical activity, ...
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Ahmad, ShafqatLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
(author)
Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan : the PROMIS study
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2015-12-18
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BioMed Central,2015
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-114014
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-114014URI
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https://doi.org/10.1186/s12881-015-0259-xDOI
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https://lup.lub.lu.se/record/8504196URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-489432URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Background: Multiple genetic variants have been reliably associated with obesity-related traits in Europeans, but little is known about their associations and interactions with lifestyle factors in South Asians.Methods: In 16,157 Pakistani adults (8232 controls; 7925 diagnosed with myocardial infarction [MI]) enrolled in the PROMIS Study, we tested whether: a) BMI-associated loci, individually or in aggregate (as a genetic risk score - GRS), are associated with BMI; b) physical activity and smoking modify the association of these loci with BMI. Analyses were adjusted for age, age(2), sex, MI (yes/no), and population substructure.Results: Of 95 SNPs studied here, 73 showed directionally consistent effects on BMI as reported in Europeans. Each additional BMI-raising allele of the GRS was associated with 0.04 (SE = 0.01) kg/m(2) higher BMI (P = 4.5 x 10(-14)). We observed nominal evidence of interactions of CLIP1 rs11583200 (P-interaction = 0.014), CADM2 rs13078960 (P-interaction = 0.037) and GALNT10 rs7715256 (P-interaction = 0.048) with physical activity, and PTBP2 rs11165643 (P-interaction = 0.045), HIP1 rs1167827 (P-interaction = 0.015), C6orf106 rs205262 (P-interaction = 0.032) and GRID1 rs7899106 (P-interaction = 0.043) with smoking on BMI.Conclusions: Most BMI-associated loci have directionally consistent effects on BMI in Pakistanis and Europeans. There were suggestive interactions of established BMI-related SNPs with smoking or physical activity.
Subject headings and genre
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Zhao, WeiPhiladelphia, PA, US
(author)
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Renström, FridaLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-frm
(author)
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Rasheed, AsifKarachi, Pakistan
(author)
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Samuel, MariaKarachi, Pakistan
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Zaidi, MozzamKarachi, Pakistan
(author)
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Shah, NabiKarachi, Pakistan; Abbottabad, Pakistan
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Mallick, Nadeem HayyatPunjab Institute of Cardiology, Lahore, Pakistan
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Zaman, Khan ShahKarachi, Pakistan
(author)
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Ishaq, MohammadKarachi, Pakistan
(author)
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Rasheed, Syed ZahedKarachi, Pakistan
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Memon, Fazal-ur-RhemanKarachi, Pakistan
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Hanif, BashirKarachi, Pakistan
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Lakhani, Muhammad ShakirKarachi, Pakistan
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Ahmed, FaisalKarachi, Pakistan
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Kazmi, Shahana UroojKarachi, Pakistan
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Frossard, PhilippeKarachi, Pakistan; Nazarbayev University, Astana, Kazakhstan
(author)
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Franks, Paul W.Lund University,Lunds universitet,Umeå universitet,Medicin,Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology(Swepub:lu)med-plf
(author)
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Saleheen, DanishPhiladelphia, PA, US; Karachi, Pakistan
(author)
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Genetisk och molekylär epidemiologiForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:BMC Medical Genetics: BioMed Central161471-2350
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Ahmad, Shafqat
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Zhao, Wei
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Renström, Frida
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Rasheed, Asif
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Samuel, Maria
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Zaidi, Mozzam
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Shah, Nabi
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Mallick, Nadeem ...
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Zaman, Khan Shah
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Ishaq, Mohammad
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Rasheed, Syed Za ...
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Memon, Fazal-ur- ...
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Hanif, Bashir
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Lakhani, Muhamma ...
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Ahmed, Faisal
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Kazmi, Shahana U ...
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Frossard, Philip ...
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Franks, Paul W.
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Saleheen, Danish
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