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Acute Myeloid Leuke...
Acute Myeloid Leukemia in Adolescents and Young Adults Treated in Pediatric and Adult Departments in the Nordic Countries
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- Wennström, Lovisa (author)
- Sahlgrens Univ Hosp, Dept Hematol & Coagulat, Dept Internal Med, Gothenburg, Sweden.
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- Edslev, Pernille Wendtland (author)
- Aarhus Univ Hosp, Dept Pediat, DK-8200 Aarhus, Denmark.
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- Abrahamsson, Jonas, 1954 (author)
- Queen Silvia Childrens Hosp, Dept Pediat, Gothenburg, Sweden.
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- Nørgaard, Jan Maxwell (author)
- Aarhus Univ Hosp, Dept Hematol, DK-8200 Aarhus, Denmark.
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- Fløisand, Yngvar (author)
- Univ Hosp, Dept Hematol, Rikshosp, Oslo, Norway.
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- Forestier, Erik (author)
- Umeå universitet,Medicinsk och klinisk genetik,Umea Univ Hosp, Dept Med Biosci, S-90185 Umea, Sweden.
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- Gustafsson, Göran (author)
- Karolinska Hosp, Children Canc Res Unit, S-10401 Stockholm, Sweden.
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- Heldrup, Jesper (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Univ Lund Hosp, Dept Pediat, S-22185 Lund, Sweden.
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- Hovi, Liisa (author)
- Univ Helsinki, Dept Pediat, Helsinki, Finland.
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- Jahnukainen, Kirsi (author)
- Univ Helsinki, Dept Pediat, Helsinki, Finland.
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- Jonsson, Olafur Gisli (author)
- Landspitalinn, Dept Pediat, Reykjavik, Iceland.
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- Lausen, Birgitte (author)
- Univ Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, DK-2100 Copenhagen, Denmark.
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- Palle, Josefine (author)
- Uppsala universitet,Pediatrik
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- Zeller, Bernward (author)
- Univ Hosp, Dept Pediat, Rigshosp, Oslo, Norway.
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- Holmberg, Erik, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Oncol, Gothenburg, Sweden.
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- Juliusson, Gunnar (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Dept Hematol, Skane Univ Hosp, Lund, Sweden.
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- Stockelberg, Dick (author)
- Sahlgrens Univ Hosp, Dept Hematol & Coagulat, Dept Internal Med, Gothenburg, Sweden.
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- Hasle, Henrik (author)
- Aarhus Univ Hosp, Dept Pediat, DK-8200 Aarhus, Denmark.
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Sahlgrens Univ Hosp, Dept Hematol & Coagulat, Dept Internal Med, Gothenburg, Sweden Aarhus Univ Hosp, Dept Pediat, DK-8200 Aarhus, Denmark. (creator_code:org_t)
- 2015-08-18
- 2016
- English.
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In: Pediatric Blood & Cancer. - : Wiley-Blackwell. - 1545-5009 .- 1545-5017. ; 63:1, s. 83-92
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Background: Studies on adolescents and young adults with acute lymphoblastic leukemia suggest better results when using pediatric protocols for adult patients, while corresponding data for acute myeloid leukemia (AML) are limited. Procedure: We investigated disease characteristics and outcome for de novo AML patients 10-30 years old treated in pediatric or adult departments. We included 166 patients 10-18 years of age with AML treated according to the pediatric NOPHO-protocols (1993-2009) compared with 253 patients aged 15-30 years treated in hematology departments (1996-2009) in the Nordic countries. Results: The incidence of AML was 4.9/million/year for the age group 10-14 years, 6.5 for 15-18 years, and 6.9 for 19-30 years. Acute promyelocytic leukemia (APL) was more frequent in adults and in females of all ages. Pediatric patients with APL had similar overall survival as pediatric patients without APL. Overall survival at 5 years was 60% (52-68%) for pediatric patients compared to 65% (58-70%) for adult patients. Cytogenetics and presenting white blood cell count were the only independent prognostic factors for overall survival. Age was not an independent prognostic factor. Conclusions: No difference was found in outcome for AML patients age 10-30 years treated according to pediatric as compared to adult protocols.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- acute myeloid leukemia
- adolescents
- age
- outcome
- young adults
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Wennström, Lovis ...
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Edslev, Pernille ...
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Abrahamsson, Jon ...
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Nørgaard, Jan Ma ...
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Fløisand, Yngvar
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Forestier, Erik
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Gustafsson, Göra ...
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Heldrup, Jesper
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Hovi, Liisa
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Jahnukainen, Kir ...
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Jonsson, Olafur ...
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Lausen, Birgitte
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Palle, Josefine
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Zeller, Bernward
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Holmberg, Erik, ...
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Juliusson, Gunna ...
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Stockelberg, Dic ...
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Hasle, Henrik
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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Pediatric Blood ...
- By the university
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Umeå University
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Lund University
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University of Gothenburg
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Uppsala University