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Prediction of the n...
Prediction of the next highly pathogenic avian influenza pandemic that can cause illness in humans
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Zhang, Zhong-Wei (author)
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Liu, Ting (author)
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Zeng, Jian (author)
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- Chen, Yang-Er (author)
- Umeå universitet,Institutionen för fysiologisk botanik,Bioinformatic Study Centre, College of Life Sciences, Sichuan Agricultural University, Ya’an 625014, China
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Yuan, Ming (author)
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Zhang, Da-Wei (author)
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Zhu, Feng (author)
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Yuan, Shu (author)
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(creator_code:org_t)
- 2015-11-27
- 2015
- English.
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In: Infectious diseases of poverty. - : BioMed Central. - 2049-9957. ; 4
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Abstract
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- Background: In recent years, avian influenza viruses (AIVs) have seriously threatened human health. Questions such as: why do AIVs infect humans?, how quickly can an AIV become pandemic?, and which virus is the most dangerous? cannot be sufficiently answered using current bioinformatic studies. Method: Secondary structures and energies of representative 5'-untranslated region (UTR) of the HA gene were calculated. Then their secondary structures and energies were re-calculated after one or two nucleotide substitutions were introduced into the HA 5'-UTR. Phylogenetic trees on the basis of hemagglutinin (HA) and polymerase basic protein 2 (PB2) amino acid sequences and HA 5'-UTR nucleotide sequences were constructed. The connection between the energy and translation efficiency of 5'-UTR was confirmed by in vitro coupled transcription/translation assay. Results: The simplicity of the secondary structure of the 5'-UTR of the HA gene determines the overall virus replication rate and transmission potential. Point mutation assays show that the 5'-UTR sequences of the HA gene in the influenza subtypes H2N2, H3N2, and H7N9 have greater variation potentials than other virus subtypes. Conclusion: Some high-virulent strains of avian influenza might emerge in the next two to three years. The H2N2 subtype, once disappeared in humans, may stage a comeback. The current outbreak of H7N9 may become pandemic and cause even more deaths, if one or two bases are substituted in the 5'-UTR sequence of the HA gene.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Avian influenza viruses
- Hemagglutinin
- Point mutation
- Translation efficiency
- 5'-untranslated region
Publication and Content Type
- ref (subject category)
- art (subject category)
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