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Pentoxifylline and vitamin E treatment for prevention of radiation-induced side-effects in women with breast cancer : a phase two, double-blind, placebo-controlled randomised clinical trial (Ptx-5)

Magnusson, Marie V (author)
Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
Höglund, Peter (author)
Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
Johansson, Karin (author)
Lund University,Lunds universitet,Människan i rörelse: hälsa och rehabilitering,Forskargrupper vid Lunds universitet,Human Movement: health and rehabilitation,Lund University Research Groups
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Jönsson, Charlotta (author)
Skåne University Hospital
Killander, Fredrika (author)
Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
Malmström, Per (author)
Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
Weddig, Anna (author)
Kjellén, Elisabeth (author)
Lund University,Lunds universitet,Umeå universitet,Institutionen för strålningsvetenskaper,Department of Oncology, Lund University Hospital, Lund, Sweden,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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 (creator_code:org_t)
Oxford : Elsevier, 2009
2009
English.
In: European Journal of Cancer. - Oxford : Elsevier. - 0959-8049 .- 1879-0852. ; 69:24, s. 740-740
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background: A previous study has shown that pentoxifylline in combination with vitamin E can reverse radiation-induced fibrosis. The aim of the present study is to investigate if the same drugs could prevent radiation-induced side-effects in women with breast cancer.Patients and methods: A randomised, placebo-controlled, double-blind, parallel group trial was performed. Women with breast cancer were treated for 12 months with 400 mg pentoxifylline t.i.d. or placebo, in combination with 100 mg vitamin E t.i.d,, starting 1-3 months after the completion of radiotherapy. The primary end-point was passive abduction of the shoulder, and the secondary end-point was difference in arm volumes. The trial is registered on the ISRCTN.org website, number ISRCTN39143623.Results: 83 patients were included in the study; 42 in the pentoxifylline + vitamin E group and 41 in the placebo + vitamin E group. Both treatments were generally well tolerated. Seven patients were withdrawn from the treatment due to disease progression; four in the pentoxifylline group and three in the placebo group. At inclusion, patients had impaired passive abduction of the shoulder. During treatment, both the groups improved significantly. Median improvement from baseline was 3.7 degrees (p = 0.0035) on pentoxifylline and was 9.4 degrees (p = 0.0041) in the placebo group, but no difference between the groups was detected (p = 0.20). Arm volumes increased over time in the placebo group (1.04%), but not on pentoxifylline (0.50%), and differed significantly between the groups (p = 0.0172).Conclusions: The combination of pentoxifylline and vitamin E was safe and may be used for the prevention of some radiation-induced side-effects. (C) 2009 Elsevier Ltd. All rights reserved.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

Pentoxifylline
Vitamin E
Breast cancer
Radiation
Fibrosis
Lymphoedema
Randomised placebo-controlled clinical trial

Publication and Content Type

ref (subject category)
art (subject category)

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