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Genome-wide associa...
Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference
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Wen, Wanqing (author)
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Kato, Norihiro (author)
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Hwang, Joo-Yeon (author)
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show more...
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Guo, Xingyi (author)
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Tabara, Yasuharu (author)
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Li, Huaixing (author)
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Dorajoo, Rajkumar (author)
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Yang, Xiaobo (author)
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Tsai, Fuu-Jen (author)
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Li, Shengxu (author)
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Wu, Ying (author)
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Wu, Tangchun (author)
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Kim, Soriul (author)
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Guo, Xiuqing (author)
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Liang, Jun (author)
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- Shungin, Dmitry (author)
- Lund University,Lunds universitet,Umeå universitet,Medicin,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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Adair, Linda S. (author)
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Akiyama, Koichi (author)
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Allison, Matthew (author)
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Cai, Qiuyin (author)
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Chang, Li-Ching (author)
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Chen, Chien-Hsiun (author)
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Chen, Yuan-Tsong (author)
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Cho, Yoon Shin (author)
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Choi, Bo Youl (author)
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Gao, Yutang (author)
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Go, Min Jin (author)
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Gu, Dongfeng (author)
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Han, Bok-Ghee (author)
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He, Meian (author)
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Hixson, James E. (author)
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Hu, Yanling (author)
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Huang, Tao (author)
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Isono, Masato (author)
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Jung, Keum Ji (author)
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Kang, Daehee (author)
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Kim, Young Jin (author)
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Kita, Yoshikuni (author)
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Lee, Juyoung (author)
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Lee, Nanette R. (author)
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Lee, Jeannette (author)
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Wang, Yiqin (author)
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Liu, Jian-Jun (author)
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Long, Jirong (author)
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Moon, Sanghoon (author)
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Nakamura, Yasuyuki (author)
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Nakatochi, Masahiro (author)
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Ohnaka, Keizo (author)
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Rao, Dabeeru (author)
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Shi, Jiajun (author)
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Sull, Jae Woong (author)
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Tan, Aihua (author)
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Ueshima, Hirotsugu (author)
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Wu, Chen (author)
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Xiang, Yong-Bing (author)
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Yamamoto, Ken (author)
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Yao, Jie (author)
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Ye, Xingwang (author)
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Yokota, Mitsuhiro (author)
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Zhang, Xiaomin (author)
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Zheng, Yan (author)
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Qi, Lu (author)
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Rotter, Jerome I. (author)
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Jee, Sun Ha (author)
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Lin, Dongxin (author)
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Mohlke, Karen L. (author)
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He, Jiang (author)
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Mo, Zengnan (author)
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Wu, Jer-Yuarn (author)
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Tai, E. Shyong (author)
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Lin, Xu (author)
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Miki, Tetsuro (author)
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Kim, Bong-Jo (author)
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Takeuchi, Fumihiko (author)
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Zheng, Wei (author)
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Shu, Xiao-Ou (author)
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(creator_code:org_t)
- 2016-01-20
- 2016
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
- Related links:
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https://umu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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http://www.ncbi.nlm....
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in Europeanancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to 17,110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3, CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI. Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci. Our study provides additional insight on genetic contribution to abdominal obesity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- genetic loci
- abdominal obesity
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Wen, Wanqing
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Kato, Norihiro
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Hwang, Joo-Yeon
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Guo, Xingyi
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Tabara, Yasuharu
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Li, Huaixing
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show more...
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Dorajoo, Rajkuma ...
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Yang, Xiaobo
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Tsai, Fuu-Jen
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Li, Shengxu
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Wu, Ying
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Wu, Tangchun
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Kim, Soriul
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Guo, Xiuqing
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Liang, Jun
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Shungin, Dmitry
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Adair, Linda S.
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Akiyama, Koichi
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Allison, Matthew
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Cai, Qiuyin
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Chang, Li-Ching
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Chen, Chien-Hsiu ...
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Chen, Yuan-Tsong
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Cho, Yoon Shin
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Choi, Bo Youl
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Gao, Yutang
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Go, Min Jin
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Gu, Dongfeng
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Han, Bok-Ghee
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He, Meian
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Hixson, James E.
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Hu, Yanling
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Huang, Tao
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Isono, Masato
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Jung, Keum Ji
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Kang, Daehee
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Kim, Young Jin
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Kita, Yoshikuni
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Lee, Juyoung
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Lee, Nanette R.
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Lee, Jeannette
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Wang, Yiqin
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Liu, Jian-Jun
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Long, Jirong
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Moon, Sanghoon
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Nakamura, Yasuyu ...
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Nakatochi, Masah ...
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Ohnaka, Keizo
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Rao, Dabeeru
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Shi, Jiajun
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Sull, Jae Woong
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Tan, Aihua
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Ueshima, Hirotsu ...
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Wu, Chen
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Xiang, Yong-Bing
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Yamamoto, Ken
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Yao, Jie
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Ye, Xingwang
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Yokota, Mitsuhir ...
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Zhang, Xiaomin
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Zheng, Yan
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Qi, Lu
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Rotter, Jerome I ...
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Jee, Sun Ha
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Lin, Dongxin
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Mohlke, Karen L.
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He, Jiang
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Mo, Zengnan
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Wu, Jer-Yuarn
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Tai, E. Shyong
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Lin, Xu
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Miki, Tetsuro
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Kim, Bong-Jo
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Takeuchi, Fumihi ...
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Zheng, Wei
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Shu, Xiao-Ou
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Scientific Repor ...
- By the university
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Umeå University
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Lund University