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Plasma carotenoids,...
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Bakker, Marije F.University Medical Center Utrecht
(author)
Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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Elsevier BV,2016
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-117384
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-117384URI
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https://doi.org/10.3945/ajcn.114.101659DOI
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https://lup.lub.lu.se/record/8576749URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:132884951URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Carotenoids and vitamin C are thought to be associated with reduced cancer risk because of their antioxidative capacity.Objective: This study evaluated the associations of plasma carotenoid, retinol, tocopherol, and vitamin C concentrations and risk of breast cancer.Design: In a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort, 1502 female incident breast cancer cases were included, with an oversampling of premenopausal (n = 582) and estrogen receptor-negative (ER-) cases (n = 462). Controls (n = 1502) were individually matched to cases by using incidence density sampling. Prediagnostic samples were analyzed for alpha-carotene, beta-carotene, lycopene, lutein, zeaxanthin, beta-cryptoxanthin, retinol, alpha-tocopherol, gamma-tocopherol, and 454 vitamin C. Breast cancer risk was computed according to hormone receptor status and age at diagnosis (proxy for menopausal status) by using conditional logistic regression and was further stratified by smoking status, alcohol consumption, and body mass index (BMI). All statistical tests were 2-sided.Results: In quintile 5 compared with quintile 1, alpha-carotene (OR: 0.61; 95% CI: 0.39, 0.98) and beta-carotene (OR: 0.41; 95% CI: 0.26, 0.65) were inversely associated with risk of ER- breast tumors. The other analytes were not statistically associated with ER- breast cancer. For estrogen receptor-positive (ER+) tumors, no statistically significant associations were found. The test for heterogeneity between ER- and ER+ tumors was statistically significant only for beta-carotene (P-heterogeneity = 0.03). A higher risk of breast cancer was found for retinol in relation to ER-/progesterone receptor-negative tumors (OR: 2.37; 95% CI: 1.20, 4.67; P-heterogeneity with ER+/progesterone receptor positive = 0.06). We observed no statistically significant interaction between smoking, alcohol, or BMI and all investigated plasma analytes (based on tertile distribution).Conclusion: Our results indicate that higher concentrations of plasma beta-carotene and alpha-carotene are associated with lower breast cancer risk of ER tumors.
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Peeters, Petra H. M.University Medical Center Utrecht
(author)
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Klaasen, Veronique M.University Medical Center Utrecht
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Bueno-de-Mesquita, H. BasUniversity Medical Center Utrecht
(author)
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Jansen, Eugene H. J. M.National Institute for Public Health and the Environment (RIVM)
(author)
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Ros, Martine M.National Institute for Public Health and the Environment (RIVM)
(author)
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Travier, NoemieCatalan Institute of Oncology
(author)
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Olsen, AnjaDanish Cancer Society
(author)
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Tjønneland, AnneDanish Cancer Society
(author)
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Overvad, KimAarhus University
(author)
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Rinaldi, Sabina
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Romieu, Isabelle
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Brennan, Paul
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Boutron-Ruault, Marie-Christine
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Perquier, Florence
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Cadeau, Claire
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Boeing, Heiner
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Aleksandrova, Krasimira
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Kaaks, Rudolf
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Kühn, Tilman
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Trichopoulou, Antonia
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Lagiou, Pagona
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Trichopoulos, Dimitrios
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Vineis, Paolo
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Krogh, Vittorio
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Panico, Salvatore
(author)
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Masala, Giovanna
(author)
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Tumino, Rosario
(author)
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Weiderpass, ElisabeteKarolinska Institutet
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Skeie, Guri
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Lund, Eiliv
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Ramon Quirós, J.
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Ardanaz, Eva
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Navarro, Carmen
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Amiano, Pilar
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Sánchez, María-José
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Buckland, Genevieve
(author)
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Ericson, UlrikaLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)medf-upe
(author)
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Sonestedt, EmilyLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Nutritionsepidemiologi,Diabetes - Cardiovascular Disease,Lund University Research Groups,Nutrition Epidemiology(Swepub:lu)medf-eso
(author)
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Johansson, MatthiasUmeå universitet,Enheten för biobanksforskning,International Agency for Research on Cancer, Lyon, France(Swepub:umu)masmas97
(author)
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Sund, MalinUmeå universitet,Kirurgi(Swepub:umu)masu0021
(author)
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Travis, Ruth C.
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Key, Timothy J.
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Khaw, Kay-Tee
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Wareham, Nick
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Riboli, Elio
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van Gils, Carla H.
(author)
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University Medical Center UtrechtNational Institute for Public Health and the Environment (RIVM)
(creator_code:org_t)
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In:American Journal of Clinical Nutrition: Elsevier BV103:2, s. 454-4640002-91651938-3207
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Bakker, Marije F ...
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Peeters, Petra H ...
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Klaasen, Veroniq ...
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Bueno-de-Mesquit ...
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Jansen, Eugene H ...
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Ros, Martine M.
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Travier, Noemie
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Olsen, Anja
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Tjønneland, Anne
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Overvad, Kim
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Rinaldi, Sabina
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Romieu, Isabelle
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Brennan, Paul
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Boutron-Ruault, ...
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Perquier, Floren ...
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Cadeau, Claire
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Boeing, Heiner
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Aleksandrova, Kr ...
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Kaaks, Rudolf
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Kühn, Tilman
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Trichopoulou, An ...
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Lagiou, Pagona
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Trichopoulos, Di ...
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Vineis, Paolo
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Krogh, Vittorio
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Panico, Salvator ...
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Masala, Giovanna
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Tumino, Rosario
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Weiderpass, Elis ...
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Skeie, Guri
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Lund, Eiliv
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Ramon Quirós, J.
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Ardanaz, Eva
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Navarro, Carmen
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Amiano, Pilar
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Sánchez, María-J ...
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Buckland, Genevi ...
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Ericson, Ulrika
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Sonestedt, Emily
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Johansson, Matth ...
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Sund, Malin
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Travis, Ruth C.
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Key, Timothy J.
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Khaw, Kay-Tee
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Wareham, Nick
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Riboli, Elio
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van Gils, Carla ...
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MEDICAL AND HEAL ...
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Umeå University
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Lund University
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Karolinska Institutet