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  • Giddaluru, Sudheer (author)

Genetics of structural connectivity and information processing in the brain

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-02-06
  • Springer Science and Business Media LLC,2016
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-117931
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-117931URI
  • https://doi.org/10.1007/s00429-016-1194-0DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-136723URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:134578270URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Understanding the genetic factors underlying brain structural connectivity is a major challenge in imaging genetics. Here, we present results from genome-wide association studies (GWASs) of whole-brain white matter (WM) fractional anisotropy (FA), an index of microstructural coherence measured using diffusion tensor imaging. Data from independent GWASs of 355 Swedish and 250 Norwegian healthy adults were integrated by meta-analysis to enhance power. Complementary GWASs on behavioral data reflecting processing speed, which is related to microstructural properties of WM pathways, were performed and integrated with WM FA results via multimodal analysis to identify shared genetic associations. One locus on chromosome 17 (rs145994492) showed genome-wide significant association with WM FA (meta P value = 1.87 × 10(-08)). Suggestive associations (Meta P value <1 × 10(-06)) were observed for 12 loci, including one containing ZFPM2 (lowest meta P value = 7.44 × 10(-08)). This locus was also implicated in multimodal analysis of WM FA and processing speed (lowest Fisher P value = 8.56 × 10(-07)). ZFPM2 is relevant in specification of corticothalamic neurons during brain development. Analysis of SNPs associated with processing speed revealed association with a locus that included SSPO (lowest meta P value = 4.37 × 10(-08)), which has been linked to commissural axon growth. An intergenic SNP (rs183854424) 14 kb downstream of CSMD1, which is implicated in schizophrenia, showed suggestive evidence of association in the WM FA meta-analysis (meta P value = 1.43 × 10(-07)) and the multimodal analysis (Fisher P value = 1 × 10(-07)). These findings provide novel data on the genetics of WM pathways and processing speed, and highlight a role of ZFPM2 and CSMD1 in information processing in the brain.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Espeseth, Thomas (author)
  • Salami, AlirezaKarolinska Institutet,Stockholms universitet,Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Aging Research Center, Karolinska Institutet and Stockholm University, 11330 Stockholm, Sweden,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Umeå University, Sweden(Swepub:umu)alsa0014 (author)
  • Westlye, Lars T (author)
  • Lundquist, AndersUmeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Statistik(Swepub:umu)anslst97 (author)
  • Christoforou, Andrea (author)
  • Cichon, Sven (author)
  • Adolfsson, RolfUmeå universitet,Psykiatri(Swepub:umu)road0001 (author)
  • Steen, Vidar M (author)
  • Reinvang, Ivar (author)
  • Nilsson, Lars GöranUmeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),ARC, Karolinska Institutet, Stockholm, Sweden (author)
  • Le Hellard, Stéphanie (author)
  • Nyberg, LarsUmeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för strålningsvetenskaper,Institutionen för integrativ medicinsk biologi (IMB)(Swepub:umu)lany0001 (author)
  • Umeå universitetUmeå centrum för funktionell hjärnavbildning (UFBI) (creator_code:org_t)

Related titles

  • In:Brain Structure and Function: Springer Science and Business Media LLC221:9, s. 4643-46611863-26531863-2661

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