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Neurofilament Level...
Neurofilament Levels as Biomarkers in Asymptomatic and Symptomatic Familial Amyotrophic Lateral Sclerosis
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2015-12-17
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Wiley,2016
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-118422
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-118422URI
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https://doi.org/10.1002/ana.24552DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Neurofilaments are elevated in the cerebrospinal fluid (CSF) and serum of amyotrophic lateral sclerosis (ALS) patients. However, timing of this increase is unknown. To characterize the premanifest disease phase, we performed a cross-sectional study on asymptomatic (n=12) and symptomatic (n=64) ALS mutation carriers and family controls (n=19). Neurofilaments NF-L (neurofilament-light chain) and pNF-H (phosphorylated neurofilament-heavy chain) are normal before symptom onset and increased by at least an order of magnitude at early symptom onset in CSF (pNF-H) or serum and CSF (NF-L). Thus, blood and CSF neurofilament levels are linked to the symptomatic phase of ALS and might serve as objective markers of structural damage to the nervous system.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Oeckl, Patrick
(author)
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Huss, Andre
(author)
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Mueller, Kathrin
(author)
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Volk, Alexander E.
(author)
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Kuhle, Jens
(author)
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Knehr, Antje
(author)
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Andersen, Peter M.Umeå universitet,Klinisk neurovetenskap,Department of Neurology, Ulm University, Ulm, Germany(Swepub:umu)pean0001
(author)
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Prudlo, Johannes
(author)
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Steinacker, Petra
(author)
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Weishaupt, Jochen H.
(author)
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Ludolph, Albert C.
(author)
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Otto, Markus
(author)
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Umeå universitetKlinisk neurovetenskap
(creator_code:org_t)
Related titles
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In:Annals of Neurology: Wiley79:1, s. 152-1580364-51341531-8249
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- By the author/editor
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Weydt, Patrick
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Oeckl, Patrick
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Huss, Andre
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Mueller, Kathrin
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Volk, Alexander ...
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Kuhle, Jens
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Knehr, Antje
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Andersen, Peter ...
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Prudlo, Johannes
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Steinacker, Petr ...
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Weishaupt, Joche ...
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Ludolph, Albert ...
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Otto, Markus
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Annals of Neurol ...
- By the university
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Umeå University