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Obesity-related met...
Obesity-related metabolite profiles of black women spanning the epidemiologic transition
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Dugas, Lara R. (author)
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- Chorell, Elin, 1981- (author)
- Umeå universitet,Medicin
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Plange-Rhule, Jacob (author)
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Lambert, Estelle V. (author)
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Cao, Guichan (author)
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Cooper, Richard S. (author)
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Layden, Brian T. (author)
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Scholten, Denise (author)
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- Olsson, Tommy, 1952- (author)
- Umeå universitet,Medicin
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Luke, Amy (author)
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Goedecke, Julia H. (author)
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(creator_code:org_t)
- 2016-02-05
- 2016
- English.
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In: Metabolomics. - New York : Springer-Verlag New York. - 1573-3882 .- 1573-3890. ; 12:3
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- In developed countries, specific metabolites have been associated with obesity and metabolic diseases, e.g. type 2 diabetes. It is unknown whether a similar profile persists across populations of African-origin, at increased risk for obesity and related diseases. In a cross-sectional study of normal-weight and obese black women (33.3 +/- 6.3 years) from the US (N = 69, 65 % obese), South Africa (SA, N = 97, 49 % obese) and Ghana (N = 82, 33 % obese) serum metabolite profiles were characterized via gas chromatography-time of flight/mass spectrometry. In US and SA women, BMI correlated with branched-chain and aromatic amino acids, as well as dopamine and aminoadipic acid. The relationship between BMI and lipid metabolites differed by site; BMI correlated positively with palmitoleic acid (16: 1) in the US; negatively with stearic acid (18: 0) in SA, and positively with arachidonic acid (20: 4) in Ghana. BMI was also positively associated with sugar-related metabolites in the US; i.e. uric acid, and mannitol, and with glucosamine, glucoronic acid and mannitol in SA. While we identified a common amino acid metabolite profile associated with obesity in black women from the US and SA, we also found site-specific obesity-related metabolites suggesting that the local environment is a key moderator of obesity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
Keyword
- Obesity
- African-origin
- Amino acid profile
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Dugas, Lara R.
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Chorell, Elin, 1 ...
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Plange-Rhule, Ja ...
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Lambert, Estelle ...
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Cao, Guichan
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Cooper, Richard ...
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show more...
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Layden, Brian T.
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Scholten, Denise
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Olsson, Tommy, 1 ...
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Luke, Amy
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Goedecke, Julia ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and General Practice
- Articles in the publication
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Metabolomics
- By the university
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Umeå University