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ANGPTL4 mediates sh...
ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure
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Dijk, Wieneke (author)
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Heine, Markus (author)
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Vergnes, Laurent (author)
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Boon, Mariëtte R. (author)
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Schaart, Gert (author)
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Hesselink, Matthijs K. C. (author)
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Reue, Karen (author)
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Lichtenbelt, Wouter D. van Marken (author)
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- Olivecrona, Gunilla (author)
- Umeå universitet,Fysiologisk kemi
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Rensen, Patrick C. N. (author)
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Heeren, Joerg (author)
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Kersten, Sander (author)
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(creator_code:org_t)
- eLife Sciences Publications, 2015
- 2015
- English.
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In: eLIFE. - : eLife Sciences Publications. - 2050-084X. ; 4
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.7...
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Abstract
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- Brown adipose tissue (BAT) activation via cold exposure is increasingly scrutinized as a potential approach to ameliorate cardio-metabolic risk. Transition to cold temperatures requires changes in the partitioning of energy substrates, re-routing fatty acids to BAT to fuel non-shivering thermogenesis. However, the mechanisms behind the redistribution of energy substrates to BAT remain largely unknown. Angiopoietin-like 4 (ANGPTL4), a protein that inhibits lipoprotein lipase (LPL) activity, is highly expressed in BAT. Here, we demonstrate that ANGPTL4 is part of a shuttling mechanism that directs fatty acids derived from circulating triglyceride-rich lipoproteins to BAT during cold. Specifically, we show that cold markedly down-regulates ANGPTL4 in BAT, likely via activation of AMPK, enhancing LPL activity and uptake of plasma triglyceride-derived fatty acids. In contrast, cold up-regulates ANGPTL4 in WAT, abolishing a cold-induced increase in LPL activity. Together, our data indicate that ANGPTL4 is an important regulator of plasma lipid partitioning during sustained cold.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Dijk, Wieneke
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Heine, Markus
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Vergnes, Laurent
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Boon, Mariëtte R ...
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Schaart, Gert
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Hesselink, Matth ...
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show more...
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Reue, Karen
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Lichtenbelt, Wou ...
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Olivecrona, Guni ...
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Rensen, Patrick ...
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Heeren, Joerg
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Kersten, Sander
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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eLIFE
- By the university
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Umeå University