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Sex steroid-related...
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Henningsson, Susanne,1977Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology,University of Gothenburg
(author)
Sex steroid-related genes and male-to-female transsexualism
- Article/chapterEnglish2005
Publisher, publication year, extent ...
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Oxford :Pergamon Press,2005
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-120411
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-120411URI
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https://doi.org/10.1016/j.psyneuen.2005.02.006DOI
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https://gup.ub.gu.se/publication/25014URI
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https://research.chalmers.se/publication/25014URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1935579URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-72511URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:121928URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Transsexualism is characterised by Lifelong discomfort with the assigned sex and a strong identification with the opposite sex. The cause of transsexualism is unknown, but it has been suggested that an aberration in the early sexual differentiation of various brain structures may be involved. Animal experiments have revealed that the sexual differentiation of the brain is mainly due to an influence of testosterone, acting both via androgen receptors (ARs) and-after aromatase-catalyzed conversion to estradiol-via estrogen receptors (ERs). The present study examined the possible importance of three polymorphisms and their pairwise interactions for the development of male-to-female transsexualism: a CAG repeat sequence in the first exon of the AR gene, a tetra nucleotide repeat polymorphism in intron 4 of the aromatase gene, and a CA repeat polymorphism in intron 5 of the ER beta gene. Subjects were 29 Caucasian male-to-female transsexuals and 229 healthy mate controls. Transsexuals differed from controls with respect to the mean Length of the ER repeat polymorphism, but not with respect to the length of the other two studied polymorphisms. However, binary logistic regression analysis revealed significant partial effects for all three polymorphisms, as well as for the interaction between the AR and aromatase gene polymorphisms, on the risk of developing transsexualism. Given the small number of transsexuals in the study, the results should be interpreted with the utmost caution. Further study of the putative role of these and other sex steroid-related genes for the development of transsexualism may, however, be worthwhile.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Westberg, Lars,1973Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology,University of Gothenburg(Swepub:gu)xwelar
(author)
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Nilsson, Staffan,1956Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)staffan
(author)
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Lundström, BengtGöteborgs universitet,University of Gothenburg
(author)
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Ekselius, LUppsala universitet,Institutionen för neurovetenskap,psykiatri, UAS(Swepub:uu)lisaekse
(author)
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Bodlund, OweUmeå universitet,Psykiatri,Umeå University(Swepub:umu)owbo0001
(author)
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Lindström, EvaUppsala universitet,Uppsala University
(author)
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Hellstrand, Monika,1955Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology,University of Gothenburg(Swepub:gu)xhelmo
(author)
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Rosmond, Roland,1966Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute,University of Gothenburg(Swepub:gu)xrosro
(author)
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Eriksson, Elias,1956Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology,University of Gothenburg(Swepub:gu)xereli
(author)
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Landén, Mikael,1966Karolinska Institutet(Swepub:gu)xlandt
(author)
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Lindström, L
(author)
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Göteborgs universitetInstitutionen för fysiologi och farmakologi, Avdelningen för farmakologi
(creator_code:org_t)
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Lundström, Bengt
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