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Physical activity and body mass index as predictors of prostate cancer risk

Grotta, Alessandra (author)
Bottai, Matteo (author)
Karolinska Institutet
Adami, Hans-Olov (author)
Karolinska Institutet
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Adams, Swann Arp (author)
Akre, Olof (author)
Karolinska Institutet
Blair, Steven Noel (author)
Mariosa, Daniela (author)
Karolinska Institutet
Nyrén, Olof (author)
Ye, Weimin (author)
Karolinska Institutet
Stattin, Pär (author)
Umeå universitet,Urologi och andrologi,Surgery and Perioperative Sciences, Urology and AndrologyUmeå University HospitalUmeåSweden
Bellocco, Rino (author)
Karolinska Institutet
Trolle Lagerros, Ylva (author)
Karolinska Institutet
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 (creator_code:org_t)
2015-01-04
2015
English.
In: World journal of urology. - : Springer Science and Business Media LLC. - 0724-4983 .- 1433-8726. ; 33:10, s. 1495-1502
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • PURPOSE: Physical activity and body mass index (BMI) are involved in prostate cancer etiology; possible biologic mechanisms include their effects on hormonal levels. Our aim was to investigate the relationship between physical activity, obesity, and prostate cancer.METHODS: We followed a cohort of 13,109 Swedish men for 13 years and investigated the association of self-reported physical activity and BMI at baseline with prostate cancer incidence. We further analyzed whether BMI could modulate effects of physical activity. Occupational, recreational, and total physical activity were analyzed in relation to overall, localized, and advanced prostate cancer.RESULTS: During the study follow-up, we observed a total of 904 cases of prostate cancer (429 localized, 407 advanced, and 68 unclassified). High levels of occupational physical activity were associated with a nonsignificantly decreased risk of overall (HR 0.81, 95 % CI 0.61-1.07), localized (HR 0.75, 95 % CI 0.51-1.12), and advanced (HR 0.85, 95 % CI 0.55-1.31) prostate cancer. We found no association between high BMI and risk of prostate cancer incidence: We observed, however, a significant interaction between BMI and leisure physical activity.CONCLUSION: No association was confirmed between total physical activity and localized or advanced prostate cancer. The highest, relative to the lowest, level of occupational physical activity tended to be linked to a lower risk of prostate cancer, with a suggested dose-response relationship. We found no association between high BMI and risk of prostate cancer incidence; however, our analyses suggested an interaction between BMI and physical activity during recreational time that merits further investigation in future studies.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

Physical activity
Body mass index
Prostate cancer
Cohort study
Epidemiology

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ref (subject category)
art (subject category)

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