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DNA Replication - A...
DNA Replication - A Matter of Fidelity
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- Ganai, Rais Ahmad (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik,Howard Hughes Medical Institute, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, NY 10016, USA
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- Johansson, Erik (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: Molecular Cell. - : Elsevier BV. - 1097-2765 .- 1097-4164. ; 62:5, s. 745-755
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http://www.cell.com/...
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https://urn.kb.se/re...
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Abstract
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- The fidelity of DNA replication is determined by many factors, here simplified as the contribution of the DNA polymerase (nucleotide selectivity and proofreading), mismatch repair, a balanced supply of nucleotides, and the condition of the DNA template (both in terms of sequence context and the presence of DNA lesions). This review discusses the contribution and interplay between these factors to the overall fidelity of DNA replication.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
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