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Thyroid Cancer afte...
Thyroid Cancer after Childhood Exposure to External Radiation : An Updated Pooled Analysis of 12 Studies
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- Veiga, Lene H. S. (författare)
- Brazilian Nuclear Energy Commission,Tel-Aviv University
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- Holmberg, Erik (författare)
- Sahlgrenska University Hospital
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- Anderson, Harald (författare)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Nordic Countries Childhood Cancer Survival Group
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- Pottern, Linda (författare)
- United States Public Health Service
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Sadetzki, Siegal (författare)
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- Adams, M. Jacob (författare)
- University of Rochester
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- Sakata, Ritsu (författare)
- Radiation Effects Research Foundation Hiroshima
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- Schneider, Arthur B. (författare)
- University of Illinois at Urbana-Champaign
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- Inskip, Peter (författare)
- National Cancer Institute, USA
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- Bhatti, Parveen (författare)
- Fred Hutchinson Cancer Research Center
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- Johansson, Robert (författare)
- Umeå University,Umeå universitet,Onkologi
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- Neta, Gila (författare)
- National Cancer Institute, USA
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- Shore, Roy (författare)
- Radiation Effects Research Foundation Hiroshima
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- de Vathaire, Florent (författare)
- Institut Gustave Roussy
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- Damber, Lena (författare)
- Umeå University,Umeå universitet,Onkologi
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- Kleinerman, Ruth (författare)
- National Cancer Institute, USA
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- Hawkins, Michael M. (författare)
- University of Birmingham
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- Tucker, Margaret (författare)
- National Cancer Institute, USA
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- Lundell, Marie (författare)
- Karolinska University Hospital
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- Lubin, Jay H. (författare)
- National Cancer Institute, USA
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(creator_code:org_t)
- 2016
- 2016
- Engelska.
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Ingår i: Radiation Research. - 0033-7587 .- 1938-5404. ; 185:5, s. 473-484
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Studies have causally linked external thyroid radiation exposure in childhood with thyroid cancer. In 1995, investigators conducted relative risk analyses of pooled data from seven epidemiologic studies. Doses were mostly <10 Gy, although childhood cancer therapies can result in thyroid doses >50 Gy. We pooled data from 12 studies of thyroid cancer patients who were exposed to radiation in childhood (ages <20 years), more than doubling the data, including 1,070 (927 exposed) thyroid cancers and 5.3 million (3.4 million exposed) person-years. Relative risks increased supralinearly through 2-4 Gy, leveled off between 10-30 Gy and declined thereafter, remaining significantly elevated above 50 Gy. There was a significant relative risk trend for doses <0.10 Gy (P < 0.01), with no departure from linearity (P = 0.36). We observed radiogenic effects for both papillary and nonpapillary tumors. Estimates of excess relative risk per Gy (ERR/Gy) were homogeneous by sex (P = 0.35) and number of radiation treatments (P = 0.84) and increased with decreasing age at the time of exposure. The ERR/Gy estimate was significant within ten years of radiation exposure, 2.76 (95% CI, 0.94-4.98), based on 42 exposed cases, and remained elevated 50 years and more after exposure. Finally, exposure to chemotherapy was significantly associated with thyroid cancer, with results supporting a nonsynergistic (additive) association with radiation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Veiga, Lene H. S ...
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Holmberg, Erik
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Anderson, Harald
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Pottern, Linda
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Sadetzki, Siegal
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Adams, M. Jacob
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visa fler...
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Sakata, Ritsu
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Schneider, Arthu ...
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Inskip, Peter
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Bhatti, Parveen
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Johansson, Rober ...
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Neta, Gila
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Shore, Roy
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de Vathaire, Flo ...
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Damber, Lena
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Kleinerman, Ruth
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Hawkins, Michael ...
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Tucker, Margaret
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Lundell, Marie
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Lubin, Jay H.
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Radiologi och bi ...
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Radiation Resear ...
- Av lärosätet
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Umeå universitet
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Karolinska Institutet
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Lunds universitet