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Association of Mult...
Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes : The EPIC-InterAct Study
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-02-09
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American Diabetes Association,2016
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-123383
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-123383URI
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https://doi.org/10.2337/dc15-0257DOI
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https://lup.lub.lu.se/record/8825922URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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OBJECTIVE Observational studies show an association between ferritin and type 2 diabetes (T2D), suggesting a role of high iron stores in T2D development. However, ferritin is influenced by factors other than iron stores, which is less the case for other biomarkers of iron metabolism. We investigated associations of ferritin, transferrin saturation (TSAT), serum iron, and transferrin with T2D incidence to clarify the role of iron in the pathogenesis of T2D.RESEARCH DESIGN AND METHODS The European Prospective Investigation into Cancer and Nutrition-InterAct study includes 12,403 incident T2D cases and a representative subcohort of 16,154 individuals from a European cohort with 3.99 million person-years of follow-up. We studied the prospective association of ferritin, TSAT, serum iron, and transferrin with incident T2D in 11,052 cases and a random subcohort of 15,182 individuals and assessed whether these associations differed by subgroups of the population.RESULTS Higher levels of ferritin and transferrin were associated with a higher risk of T2D (hazard ratio [HR] [95% CI] in men and women, respectively: 1.07 [1.01-1.12] and 1.12 [1.05-1.19] per 100mg/L higher ferritin level; 1.11 [1.00-1.24] and 1.22 [1.12-1.33] per 0.5 g/L higher transferrin level) after adjustment for age, center, BMI, physical activity, smoking status, education, hs-CRP, alanine aminotransferase, and g-glutamyl transferase. Elevated TSAT (>= 45% vs. <45%) was associated with a lower risk of T2D in women (0.68 [0.54-0.86]) but was not statistically significantly associated in men (0.90 [0.75-1.08]). Serum iron was not associated with T2D. The association of ferritin with T2D was stronger among leaner individuals (P-interaction < 0.01).CONCLUSIONS The pattern of association of TSAT and transferrin with T2D suggests that the underlying relationship between iron stores and T2D is more complex than the simple link suggested by the association of ferritin with T2D.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Meidtner, Karina
(author)
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Schulze, Matthias B.
(author)
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Scott, Robert A.
(author)
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Ramond, Anna
(author)
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Butterworth, Adam S.
(author)
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Di Angelantonio, Emanuele
(author)
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Danesh, John
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Arriola, Larraitz
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Barricarte, Aurelio
(author)
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Boeing, Heiner
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Clavel-Chapelon, Francoise
(author)
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Cross, Amanda J.
(author)
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Dahm, Christina C.
(author)
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Fagherazzi, Guy
(author)
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Franks, Paul W.Lund University,Lunds universitet,Umeå universitet,Medicin,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-plf
(author)
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Gavrila, Diana
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Grioni, Sara
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Gunter, Marc J.
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Gusto, Gaelle
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Jakszyn, Paula
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Katzke, Verena
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Key, Timothy J.
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Kuhn, Tilman
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Mattiello, Amalia
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Nilsson, PeterLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-pni
(author)
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Olsen, Anja
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Overvad, Kim
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Palli, Domenico
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Ramon Quiros, J.
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Rolandsson, OlovUmeå universitet,Allmänmedicin(Swepub:umu)olro0005
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Sacerdote, Carlotta
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Sanchez-Cantalejo, Emilio
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Slimani, Nadia
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Sluijs, Ivonne
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Spijkerman, Annemieke M. W.
(author)
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Tjonneland, Anne
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Tumino, Rosario
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van der A, Daphne L.
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van der Schouw, Yvonne T.
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Feskens, Edith J. M.
(author)
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Forouhi, Nita G.
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Sharp, Stephen J.
(author)
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Riboli, Elio
(author)
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Langenberg, Claudia
(author)
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Wareham, Nicholas J.
(author)
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Umeå universitetMedicin
(creator_code:org_t)
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In:Diabetes Care: American Diabetes Association39:4, s. 572-5810149-59921935-5548
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Podmore, Clara
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Meidtner, Karina
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Schulze, Matthia ...
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Scott, Robert A.
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Ramond, Anna
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Butterworth, Ada ...
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Di Angelantonio, ...
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Danesh, John
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Arriola, Larrait ...
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Barricarte, Aure ...
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Boeing, Heiner
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Clavel-Chapelon, ...
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Cross, Amanda J.
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Dahm, Christina ...
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Fagherazzi, Guy
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Franks, Paul W.
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Gavrila, Diana
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Grioni, Sara
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Gunter, Marc J.
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Gusto, Gaelle
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Jakszyn, Paula
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Katzke, Verena
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Key, Timothy J.
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Kuhn, Tilman
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Mattiello, Amali ...
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Nilsson, Peter
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Olsen, Anja
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Overvad, Kim
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Palli, Domenico
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Ramon Quiros, J.
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Rolandsson, Olov
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Sacerdote, Carlo ...
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Sanchez-Cantalej ...
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Slimani, Nadia
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Sluijs, Ivonne
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Spijkerman, Anne ...
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Tjonneland, Anne
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Tumino, Rosario
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van der A, Daphn ...
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van der Schouw, ...
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Feskens, Edith J ...
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Forouhi, Nita G.
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Sharp, Stephen J ...
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Riboli, Elio
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Langenberg, Clau ...
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Wareham, Nichola ...
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Diabetes Care
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Umeå University
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