Search: onr:"swepub:oai:DiVA.org:umu-124226" >
A method to deciphe...
A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases
-
Han, Buhm (author)
-
Pouget, Jennie G. (author)
-
Slowikowski, Kamil (author)
-
show more...
-
Stahl, Eli (author)
-
Lee, Cue Hyunkyu (author)
-
Diogo, Dorothee (author)
-
Hu, Xinli (author)
-
Park, Yu Rang (author)
-
Kim, Eunji (author)
-
Gregersen, Peter K. (author)
-
- Dahlqvist, Solbritt Rantapää (author)
- Umeå universitet,Reumatologi
-
Worthington, Jane (author)
-
Martin, Javier (author)
-
Eyre, Steve (author)
-
- Klareskog, Lars (author)
- Karolinska Institutet
-
Huizinga, Tom (author)
-
Chen, Wei-Min (author)
-
Onengut-Gumuscu, Suna (author)
-
Rich, Stephen S. (author)
-
Wray, Naomi R. (author)
-
Raychaudhuri, Soumya (author)
-
show less...
-
(creator_code:org_t)
- 2016-05-16
- 2016
- English.
-
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 48:7, s. 803-
- Related links:
-
https://www.research...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- There is growing evidence of shared risk alleles for complex traits (pleiotropy), including autoimmune and neuropsychiatric diseases. This might be due to sharing among all individuals (whole-group pleiotropy) or a subset of individuals in a genetically heterogeneous cohort (subgroup heterogeneity). Here we describe the use of a well-powered statistic, BUHMBOX, to distinguish between those two situations using genotype data. We observed a shared genetic basis for 11 autoimmune diseases and type 1 diabetes (T1D; P < 1 x 10(-4)) and for 11 autoimmune diseases and rheumatoid arthritis (RA; P < 1 x 10(-3)). This sharing was not explained by subgroup heterogeneity (corrected P-BUHMBOX > 0.2; 6,670 T1D cases and 7,279 RA cases). Genetic sharing between seronegative and seropostive RA (P < 1 x 10(-9)) had significant evidence of subgroup heterogeneity, suggesting a subgroup of seropositive-like cases within seronegative cases (P-BUHMBOX = 0.008; 2,406 seronegative RA cases). We also observed a shared genetic basis for major depressive disorder (MDD) and schizophrenia (P < 1 x 10(-4)) that was not explained by subgroup heterogeneity (P-BUHMBOX = 0.28; 9,238 MDD cases).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Han, Buhm
-
Pouget, Jennie G ...
-
Slowikowski, Kam ...
-
Stahl, Eli
-
Lee, Cue Hyunkyu
-
Diogo, Dorothee
-
show more...
-
Hu, Xinli
-
Park, Yu Rang
-
Kim, Eunji
-
Gregersen, Peter ...
-
Dahlqvist, Solbr ...
-
Worthington, Jan ...
-
Martin, Javier
-
Eyre, Steve
-
Klareskog, Lars
-
Huizinga, Tom
-
Chen, Wei-Min
-
Onengut-Gumuscu, ...
-
Rich, Stephen S.
-
Wray, Naomi R.
-
Raychaudhuri, So ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
- Articles in the publication
-
Nature Genetics
- By the university
-
Umeå University
-
Karolinska Institutet