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Design and Synthesi...
Design and Synthesis of 2,2'-Diindolylmethanes to Selectively Target Certain G-Quadruplex DNA Structures
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- Livendahl, Madeleine (author)
- Umeå universitet,Kemiska institutionen
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- Jamroskovic, Jan (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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- Ivanova, Svetlana (author)
- Umeå universitet,Kemiska institutionen
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- Demirel, Peter (author)
- Umeå universitet,Kemiska institutionen
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- Sabouri, Nasim (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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- Chorell, Erik (author)
- Umeå universitet,Kemiska institutionen
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(creator_code:org_t)
- 2016-08-09
- 2016
- English.
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In: Chemistry - A European Journal. - : Wiley. - 0947-6539 .- 1521-3765. ; 22:37, s. 13004-13009
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- G-quadruplex (G4) structures carry vital biological functions, and compounds that selectively target certain G4 structures have both therapeutic potential and value as research tools. Along this line, 2,2'-diindolylmethanes have been designed and synthesized in this work based on the condensation of 3,6- or 3,7-disubstituted indoles with aldehydes. The developed class of compounds efficiently stabilizes G4 structures without inducing conformational changes in such structures. Furthermore, the 2,2'-diindolylmethanes target certain G4 structures more efficiently than others and this G4 selectivity can be altered by chemical modifications of the compounds.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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