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Gender and age effe...
Gender and age effects on risk factor-based prediction of coronary artery calcium in symptomatic patients : a Euro-CCAD study
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- Nicoll, Rachel (author)
- Umeå universitet,Kardiologi,Heart Centre
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- Wiklund, Urban (author)
- Umeå universitet,Institutionen för strålningsvetenskaper
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Zhao, Ying (author)
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Diederichsen, A. (author)
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Mickley, H. (author)
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Ovrehus, K. (author)
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Zamorano, J. (author)
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Gueret, P. (author)
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Schmermund, A. (author)
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Maffei, E. (author)
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Cademartiri, F. (author)
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Budoff, M. (author)
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- Henein, Michael (author)
- Umeå universitet,Kardiologi,Heart Centre
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(creator_code:org_t)
- Elsevier, 2016
- 2016
- English.
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In: Atherosclerosis. - : Elsevier. - 0021-9150 .- 1879-1484. ; 252, s. 32-39
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background and aims: The influence of gender and age on risk factor prediction of coronary artery calcification (CAC) presence in symptomatic patients is unclear.Methods: From the European Calcific Coronary Artery Disease (EURO-CCAD) cohort, we retrospectively investigated 6309 symptomatic patients, 62% male, from Denmark, France, Germany, Italy, Spain and USA. All had risk factor assessment and CT scanning for CAC scoring. Results: The prevalence of CAC among females was lower than among males in all age groups. Using multivariate logistic regression, age, dyslipidaemia, hypertension, diabetes and smoking were independently predictive of CAC presence in both genders. In addition to a progressive increase in CAC with age, the most important predictors of CAC presence were dyslipidaemia and diabetes (β = 0.64 and 0.63 respectively) in males and diabetes (β = 1.08) followed by smoking (β = 0.68) in females; these same risk factors were also important in predicting increasing CAC scores. There was no difference in the predictive ability of diabetes, hypertension and dyslipidaemia in either gender for CAC presence in patients aged <50 and 50-70 years. However, in patients aged >70, only dyslipidaemia predicted CAC presence in males and only smoking and diabetes were predictive in females. Conclusion: In symptomatic patients, there are significant differences in the ability of conventional risk factors to predict CAC presence between genders and between patients aged <70 and ≥70, indicating the important role of age in predicting CAC presence.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Coronary calcification
- age
- gender
- risk factors
- Cardiology
- kardiologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Nicoll, Rachel
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Wiklund, Urban
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Zhao, Ying
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Diederichsen, A.
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Mickley, H.
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Ovrehus, K.
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show more...
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Zamorano, J.
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Gueret, P.
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Schmermund, A.
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Maffei, E.
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Cademartiri, F.
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Budoff, M.
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Henein, Michael
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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Atherosclerosis
- By the university
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Umeå University