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Benefits of a Paleo...
Benefits of a Paleolithic diet with and without supervised exercise on fat mass, insulin sensitivity, and glycemic control : a randomized controlled trial in individuals with type 2 diabetes
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- Otten, Julia, 1973- (author)
- Umeå universitet,Medicin,Tommy Olsson
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- Stomby, Andreas (author)
- Umeå universitet,Medicin
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- Waling, Maria, 1981- (author)
- Umeå universitet,Institutionen för kostvetenskap
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- Isaksson, Andreas (author)
- Umeå universitet,Idrottsmedicin
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- Tellström, Anna (author)
- Umeå universitet,Medicin
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- Lundin-Olsson, Lillemor (author)
- Umeå universitet,Fysioterapi
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Brage, Søren (author)
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- Ryberg, Mats (author)
- Umeå universitet,Medicin
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- Svensson, Michael (author)
- Umeå universitet,Idrottsmedicin
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- Olsson, Tommy (author)
- Umeå universitet,Medicin
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(creator_code:org_t)
- 2016-06-30
- 2017
- English.
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In: Diabetes/Metabolism Research Reviews. - : Wiley. - 1520-7552 .- 1520-7560. ; 33:1
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Abstract
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- BackgroundMeans to reduce future risk for cardiovascular disease in subjects with type 2 diabetes are urgently needed.MethodsThirty-two patients with type 2 diabetes (age 59 ± 8 years) followed a Paleolithic diet for 12 weeks. Participants were randomized to either standard care exercise recommendations (PD) or 1-h supervised exercise sessions (aerobic exercise and resistance training) three times per week (PD-EX).ResultsFor the within group analyses, fat mass decreased by 5.7 kg (IQR: −6.6, −4.1; p < 0.001) in the PD group and by 6.7 kg (−8.2, −5.3; p < 0.001) in the PD-EX group. Insulin sensitivity (HOMA-IR) improved by 45% in the PD (p < 0.001) and PD-EX (p < 0.001) groups. HbA1c decreased by 0.9% (−1.2, −0.6; p < 0.001) in the PD group and 1.1% (−1.7, −0.7; p < 0.01) in the PD-EX group. Leptin decreased by 62% (p < 0.001) in the PD group and 42% (p < 0.001) in the PD-EX group. Maximum oxygen uptake increased by 0.2 L/min (0.0, 0.3) in the PD-EX group, and remained unchanged in the PD group (p < 0.01 for the difference between intervention groups). Male participants decreased lean mass by 2.6 kg (−3.6, −1.3) in the PD group and by 1.2 kg (−1.3, 1.0) in the PD-EX group (p < 0.05 for the difference between intervention groups).ConclusionsA Paleolithic diet improves fat mass and metabolic balance including insulin sensitivity, glycemic control, and leptin in subjects with type 2 diabetes. Supervised exercise training may not enhance the effects on these outcomes, but preserves lean mass in men and increases cardiovascular fitness.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- type 2 diabetes
- Paleolithic diet
- diet intervention
- exercise
- glycosyl-ated haemoglobin A
- insulin sensitivity
- leptin
Publication and Content Type
- ref (subject category)
- art (subject category)
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Otten, Julia, 19 ...
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Stomby, Andreas
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Waling, Maria, 1 ...
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Isaksson, Andrea ...
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Tellström, Anna
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Lundin-Olsson, L ...
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Brage, Søren
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Ryberg, Mats
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Svensson, Michae ...
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Olsson, Tommy
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Diabetes/Metabol ...
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Umeå University