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Prediagnostic selen...
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Hughes, David J.
(author)
Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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Elsevier BV,2016
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-126626
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-126626URI
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https://doi.org/10.3945/ajcn.116.131672DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:134044230URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Selenium status is suboptimal in many Europeans and may be a risk factor for the development of various cancers, including those of the liver and biliary tract.Objective: We wished to examine whether selenium status in advance of cancer onset is associated with hepatobiliary cancers in the EPIC (European Prospective Investigation into Cancer and Nutrition) study.Design: We assessed prediagnostic selenium status by measuring serum concentrations of selenium and selenoprotein P (SePP; the major circulating selenium transfer protein) and examined the association with hepatocellular carcinoma (HCC; n = 121), gallbladder and biliary tract cancers (GBTCs; n = 100), and intrahepatic bile duct cancer (IHBC; n = 40) risk in a nested case-control design within the EPIC study. Selenium was measured by total reflection X-ray fluorescence, and SePP was determined by a colorimetric sandwich ELISA. Multivariable ORs and 95% CIs were calculated by using conditional logistic regression.Results: HCC and GBTC cases, but not IHBC cases, showed significantly lower circulating selenium and SePP concentrations than their matched controls. Higher circulating selenium was associated with a significantly lower HCC risk (OR per 20-mg/L increase: 0.41; 95% CI: 0.23, 0.72) but not with the risk of GBTC or IHBC. Similarly, higher SePP concentrations were associated with lowered HCC risk only in both the categorical and continuous analyses (HCC: P-trend <= 0.0001; OR per 1.5-mg/L increase: 0.37; 95% CI: 0.21, 0.63).Conclusion: These findings from a large prospective cohort provide evidence that suboptimal selenium status in Europeans may be associated with an appreciably increased risk of HCC development.
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Duarte-Salles, Talita
(author)
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Hybsier, Sandra
(author)
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Trichopoulou, Antonia
(author)
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Stepien, Magdalena
(author)
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Aleksandrova, Krasimira
(author)
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Overvad, Kim
(author)
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Tjonneland, Anne
(author)
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Olsen, Anja
(author)
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Affret, Aurelie
(author)
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Fagherazzi, Guy
(author)
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Boutron-Ruault, Marie-Christine
(author)
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Katzke, Verena
(author)
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Kaaks, Rudolf
(author)
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Boeing, Heiner
(author)
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Bamia, Christina
(author)
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Lagiou, Pagona
(author)
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Peppa, Eleni
(author)
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Palli, Domenico
(author)
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Krogh, Vittorio
(author)
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Panico, Salvatore
(author)
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Tumino, Rosario
(author)
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Sacerdote, Carlotta
(author)
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Bueno-de-Mesquita, Hendrik Bastiaan
(author)
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Peeters, Petra H.
(author)
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Engeset, Dagrun
(author)
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Weiderpass, ElisabeteKarolinska Institutet
(author)
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Lasheras, Cristina
(author)
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Agudo, Antonio
(author)
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Sanchez, Maria-Jose
(author)
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Navarro, Carmen
(author)
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Ardanaz, Eva
(author)
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Dorronsoro, Miren
(author)
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Hemmingsson, OskarUmeå universitet,Kirurgi(Swepub:umu)osrhen96
(author)
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Wareham, Nicholas J.
(author)
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Khaw, Kay-Tee
(author)
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Bradbury, Kathryn E.
(author)
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Cross, Amanda J.
(author)
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Gunter, Marc
(author)
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Riboli, Elio
(author)
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Romieu, Isabelle
(author)
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Schomburg, Lutz
(author)
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Jenab, Mazda
(author)
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Karolinska InstitutetKirurgi
(creator_code:org_t)
Related titles
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In:American Journal of Clinical Nutrition: Elsevier BV104:2, s. 406-4140002-91651938-3207
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Hughes, David J.
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Duarte-Salles, T ...
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Hybsier, Sandra
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Trichopoulou, An ...
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Stepien, Magdale ...
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Aleksandrova, Kr ...
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Overvad, Kim
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Tjonneland, Anne
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Olsen, Anja
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Affret, Aurelie
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Fagherazzi, Guy
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Boutron-Ruault, ...
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Katzke, Verena
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Kaaks, Rudolf
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Boeing, Heiner
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Bamia, Christina
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Lagiou, Pagona
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Peppa, Eleni
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Palli, Domenico
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Krogh, Vittorio
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Panico, Salvator ...
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Tumino, Rosario
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Sacerdote, Carlo ...
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Bueno-de-Mesquit ...
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Peeters, Petra H ...
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Engeset, Dagrun
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Weiderpass, Elis ...
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Lasheras, Cristi ...
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Agudo, Antonio
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Sanchez, Maria-J ...
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Navarro, Carmen
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Ardanaz, Eva
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Dorronsoro, Mire ...
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Hemmingsson, Osk ...
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Wareham, Nichola ...
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Khaw, Kay-Tee
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Bradbury, Kathry ...
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Cross, Amanda J.
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Gunter, Marc
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Riboli, Elio
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Romieu, Isabelle
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Schomburg, Lutz
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Jenab, Mazda
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Cancer and Oncol ...
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MEDICAL AND HEAL ...
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and Nutrition and Di ...
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Umeå University
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Karolinska Institutet