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A Prospective Evalu...
A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort
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- Terry, Kathryn L. (author)
- Harvard University
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- Schock, Helena (author)
- German Cancer Research Centre
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- Fortner, Renée T. (author)
- German Cancer Research Centre
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- Hüsing, Anika (author)
- German Cancer Research Centre
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- Fichorova, Raina N. (author)
- Brigham and Women's Hospital / Harvard Medical School
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- Yamamoto, Hidemi S. (author)
- Brigham and Women's Hospital / Harvard Medical School
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- Vitonis, Allison F. (author)
- Brigham and Women's Hospital / Harvard Medical School
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- Johnson, Theron (author)
- German Cancer Research Centre
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- Overvad, Kim (author)
- Aarhus University
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- Tjønneland, Anne (author)
- Danish Cancer Society
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Boutron-Ruault, Marie-Christine (author)
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Mesrine, Sylvie (author)
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Severi, Gianluca (author)
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Dossus, Laure (author)
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Rinaldi, Sabina (author)
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Boeing, Heiner (author)
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Benetou, Vassiliki (author)
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Lagiou, Pagona (author)
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Trichopoulou, Antonia (author)
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Krogh, Vittorio (author)
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Kuhn, Elisabetta (author)
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Panico, Salvatore (author)
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Bueno-de-Mesquita, H. Bas (author)
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Onland-Moret, N. Charlotte (author)
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Peeters, Petra H. (author)
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Gram, Inger Torhild (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Duell, Eric J. (author)
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Sanchez, Maria-Jose (author)
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Ardanaz, Eva (author)
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Etxezarreta, Nerea (author)
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Navarro, Carmen (author)
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- Idahl, Annika (author)
- Umeå universitet,Obstetrik och gynekologi
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- Lundin, Eva (author)
- Umeå universitet,Patologi
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- Jirström, Karin (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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Wareham, Nicholas J. (author)
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Khaw, Kay-Tee (author)
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Byrne, Karl Smith (author)
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Travis, Ruth C. (author)
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Gunter, Marc J. (author)
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Merritt, Melissa A. (author)
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Riboli, Elio (author)
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Cramer, Daniel W. (author)
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Kaaks, Rudolf (author)
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(creator_code:org_t)
- American Association for Cancer Research, 2016
- 2016
- English.
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In: Clinical Cancer Research. - : American Association for Cancer Research. - 1078-0432 .- 1557-3265. ; 22:18, s. 4664-4675
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Purpose: About 60% of ovarian cancers are diagnosed at late stage, when 5-year survival is less than 30% in contrast to 90% for local disease. This has prompted search for early detection biomarkers. For initial testing, specimens taken months or years before ovarian cancer diagnosis are the best source of information to evaluate earlydetection biomarkers. Here we evaluate the most promising ovarian cancer screening biomarkers in prospectively collected samples from the European Prospective Investigation into Cancer and Nutrition study. Experimental Design: We measured CA125, HE4, CA72.4, and CA15.3 in 810 invasive epithelial ovarian cancer cases and 1,939 controls. We calculated the sensitivity at 95% and 98% specificity as well as area under the receiver operator curve (C-statistic) for each marker individually and in combination. In addition, we evaluated marker performance by stage at diagnosis and time between blood draw and diagnosis. Results: We observed the best discrimination between cases and controls within 6 months of diagnosis for CA125 (C-statistic = 0.92), then HE4 (0.84), CA72.4 (0.77), and CA15.3 (0.73). Marker performance declined with longer time between blood draw and diagnosis and for earlier staged disease. However, assessment of discriminatory ability at early stage was limited by small numbers. Combinations of markers performed modestly, but significantly better than any single marker. Conclusions: CA125 remains the single best marker for the early detection of invasive epithelial ovarian cancer, but can be slightly improved by combining with other markers. Identifying novel markers for ovarian cancer will require studies including larger numbers of early-stage cases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Terry, Kathryn L ...
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Schock, Helena
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Fortner, Renée T ...
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Hüsing, Anika
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Fichorova, Raina ...
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Yamamoto, Hidemi ...
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show more...
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Vitonis, Allison ...
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Johnson, Theron
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Overvad, Kim
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Tjønneland, Anne
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Boutron-Ruault, ...
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Mesrine, Sylvie
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Severi, Gianluca
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Dossus, Laure
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Rinaldi, Sabina
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Boeing, Heiner
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Benetou, Vassili ...
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Lagiou, Pagona
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Trichopoulou, An ...
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Krogh, Vittorio
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Kuhn, Elisabetta
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Panico, Salvator ...
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Bueno-de-Mesquit ...
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Onland-Moret, N. ...
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Peeters, Petra H ...
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Gram, Inger Torh ...
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Weiderpass, Elis ...
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Duell, Eric J.
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Sanchez, Maria-J ...
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Ardanaz, Eva
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Etxezarreta, Ner ...
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Navarro, Carmen
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Idahl, Annika
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Lundin, Eva
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Jirström, Karin
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Manjer, Jonas
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Wareham, Nichola ...
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Khaw, Kay-Tee
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Byrne, Karl Smit ...
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Travis, Ruth C.
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Gunter, Marc J.
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Merritt, Melissa ...
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Riboli, Elio
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Cramer, Daniel W ...
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Kaaks, Rudolf
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Clinical Cancer ...
- By the university
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Umeå University
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Karolinska Institutet
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Lund University