Search: onr:"swepub:oai:DiVA.org:umu-12683" >
Hypertrophic muscle...
-
Eriksson, AndersLuleå tekniska universitet,Umeå universitet,Anatomi,Medicinsk vetenskap
(author)
Hypertrophic muscle fibers with fissures in power-lifters; fiber splitting or defect regeneration?
- Article/chapterEnglish2006
Publisher, publication year, extent ...
-
2006-04-20
-
Springer Science and Business Media LLC,2006
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:umu-12683
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-12683URI
-
https://doi.org/10.1007/s00418-006-0176-3DOI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-6270URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Validerad; 2006; 20070402 (andbra)
-
Power-lifters have hypertrophic muscle fibers with fissures seen in cross-sections, called as fiber splitting.Whether this phenomenon is due to real splitting or defective regeneration has not been settled. To elucidate this matter,we have examined biopsies from the trapezius and vastus lateralis of power lifters (P group) and power lifters self-administrating anabolic steroids (PAS group). For this purpose, immunohistochemical staining of serial cross -sections was used. The PAS group had significantly more fibers with fissures than the P group in the vastus lateralis (1.2%+/-0.95% vs 0.35+/-0.34, P < 0.05) but not in the trapezius muscle (1.7% in both groups). Serial sections revealed that the fibers with fissures changed their profile profoundly over short distances. Some such fibers had a mature staining profile, whereas other fibers indicated recent degeneration and/or regeneration. Activation of satellite cells and formation of aberrant segments were also evident. We conclude that the so-called split fibers are due to defect regeneration. Some fibers with fissures are the results of old events of segmental muscle fiber damage, whereas the others reflect an ongoing process. The normal regenerative process is most likely disturbed in power-lifters by their continuous training with repeated high mechanical stress on the muscles.
Subject headings and genre
-
Adult
-
Anabolic Agents/administration & dosage
-
Humans
-
Hypertrophy
-
Immunohistochemistry
-
Male
-
Muscle Fibers/*pathology/*physiology
-
Muscle; Skeletal/drug effects/ultrastructure
-
Regeneration
-
Self Administration
-
Steroids/administration & dosage
-
Weight Lifting
Added entries (persons, corporate bodies, meetings, titles ...)
-
Lindström, Mona,1961-Umeå universitet,Anatomi,Umeå University, Department of Integrative Medical Biology(Swepub:umu)moli0003
(author)
-
Carlsson, LenaUmeå universitet,Anatomi,Umeå University, Department of Integrative Medical Biology(Swepub:umu)leca0003
(author)
-
Thornell, Lars-EricUmeå universitet,Anatomi,Umeå University, Department of Integrative Medical Biology(Swepub:umu)lath0002
(author)
-
Umeå universitetAnatomi
(creator_code:org_t)
Related titles
-
In:Histochemistry and Cell Biology: Springer Science and Business Media LLC126:4, s. 409-4170948-61431432-119X
Internet link
Find in a library
To the university's database