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Nonlinear relations...
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Lukanova, Annekatrin
(author)
Nonlinear relationship of insulin-like growth factor (IGF)-I and IGF-I/IGF-binding protein-3 ratio with indices of adiposity and plasma insulin concentrations (Sweden).
- Article/chapterEnglish2002
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LIBRIS-ID:oai:DiVA.org:umu-127167
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-127167URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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OBJECTIVE: In this study we test the hypothesis of a nonlinear relationship of IGF-I with indices of body fat such as body mass index (BMI), insulin, and leptin.METHODS: The controls used in three case-control cancer studies nested in the Northern Sweden Health and Disease Cohort, were combined for this analysis. Measurements of plasma IGF-I, IGFBP-3, insulin, and leptin were available for 445 men and 391 women.RESULTS: In both men and women we found the highest mean IGF-I levels in subjects with BMI between 24 and 26. IGF-I concentrations decreased toward BMI < or = 20 and BMI > 30 in men; however, the results for women did not reach statistical significance. The molar ratio of IGF-I/IGFBP-3 showed a similar profile to that of IGF-I, although much less pronounced. The observed peak mean IGF-I levels in the second quintiles of insulin and leptin in men supported these findings. No significant variation of mean IGF-I levels across quintiles of insulin and leptin were observed in women.CONCLUSIONS: The results of this study provide evidence that IGF-I plasma concentrations vary substantially over a wide range of body weight and that the relationship is nonlinear.
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Söderberg, StefanUmeå universitet,Kardiologi(Swepub:umu)stso0001
(author)
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Stattin, Pär
(author)
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Palmqvist, Richard
(author)
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Lundin, Eva
(author)
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Biessy, Carine
(author)
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Rinaldi, Sabina
(author)
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Riboli, Elio
(author)
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Hallmans, Göran
(author)
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Kaaks, Rudolf
(author)
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Umeå universitetKardiologi
(creator_code:org_t)
Related titles
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In:Cancer Causes and Control13:6, s. 509-5160957-52431573-7225
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Lukanova, Anneka ...
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Söderberg, Stefa ...
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Stattin, Pär
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Palmqvist, Richa ...
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Lundin, Eva
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Biessy, Carine
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Rinaldi, Sabina
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Riboli, Elio
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Hallmans, Göran
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Kaaks, Rudolf
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- MEDICAL AND HEALTH SCIENCES
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and Clinical Medicin ...
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Cancer Causes an ...
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Umeå University