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  • Tikkanen, R.Rinnekoti Foundation Finland,University of Helsinki,Helsinki University Central Hospital (författare)

Influence of a HTR2B Stop Codon on Glucagon Homeostasis and Glucose Excursion in Non-Diabetic Men

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • 2016-07-20
  • Georg Thieme Verlag KG,2016
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-127723
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-127723URI
  • https://doi.org/10.1055/s-0042-109263DOI
  • https://lup.lub.lu.se/record/14b5fde8-af9e-4f1e-aa41-b60ee561c439URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:134452449URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Limited data are available about the role of the serotonin 2B (5-HT2B) receptor in the function of human islets. This study aimed to test whether the 5-HT2B receptor contributes to glucose, insulin, and glucagon homeostasis in humans, utilizing a hereditary loss-of-function gene mutation in the receptor, which causes a 50% reduction in the production of the receptor protein in heterozygotes. This clinical study enrolled participants recruited by newspaper advertisements and from mental status examinations. A cohort of participants from a young Finnish founder population composed of 68 non-diabetic males with a mean age of 30 was divided into groups for comparison based on being a 5-HT2B receptor loss-of-function gene mutation (HTR2B Q20*) heterozygote carrier (n=11) or not (n=57). Serum levels of glucose, insulin, and glucagon were measured in a 5h oral glucose tolerance test using a 75g glucose challenge. Insulin resistance, insulin sensitivity, and beta cell activity were calculated using the homeostasis model assessment (HOMA2) and whole body insulin sensitivity index (WBISI), as well as the ratio of glucagon to insulin was noted. The areas under the curves (AUCs) were also determined. Concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) were measured in cerebrospinal fluid (CSF). Covariate adjusted mean score comparisons were applied. Lower glucagon secretion and decreased glucose excursion were observed among HTR2B Q20* carriers as compared with individuals who were homozygotes for the wild-type Q20 allele (controls). No differences in insulin secretion, beta cell activity, insulin resistance, or insulin sensitivity were observed. The glucagon to insulin ratio differed between the HTR2B Q20* carriers and controls. CSF levels of 5-HIAA were similar between groups. Our findings indicate that the 5-HT2B receptor may contribute to the regulation of human glucagon and glucose homeostasis and the interplay between glucagon and insulin secretion.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Saukkonen, T.Helsinki University Central Hospital,University of Helsinki,Novo Nordisk A/S (författare)
  • Fex, M.Lund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medk-mf0 (författare)
  • Bennet, H.Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-hgb (författare)
  • Rautiainen, M. -RFinnish National Institute for Health and Welfare (författare)
  • Paunio, T.University of Helsinki,Finnish National Institute for Health and Welfare (författare)
  • Koskinen, M.Oy Aava Development Ltd. (författare)
  • Panarsky, R.National Institute on Alcohol Abuse and Alcoholism (författare)
  • Bevilacqua, L.New York University (författare)
  • Sjöberg, Rickard L.Umeå University,Umeå universitet,Klinisk neurovetenskap(Swepub:umu)risj0004 (författare)
  • Tiihonen, J.Karolinska Institutet,Umeå University,Umeå universitet,Klinisk neurovetenskap,National Institute for Health and Welfare, Helsinki, Finland; Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland,Finnish National Institute for Health and Welfare (författare)
  • Virkkunen, M.University of Helsinki (författare)
  • Rinnekoti Foundation FinlandUniversity of Helsinki (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Experimental and clinical endocrinology & diabetes: Georg Thieme Verlag KG124:9, s. 529-5340947-73491439-3646

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