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Multicenter validat...
Multicenter validation of CSF neurofilaments as diagnostic biomarkers for ALS
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-04-11
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Informa UK Limited,2016
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-127982
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-127982URI
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https://doi.org/10.3109/21678421.2016.1167913DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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OBJECTIVE: Neurofilaments are leading neurochemical biomarkers for amyotrophic lateral sclerosis (ALS). Here, we investigated the effect of preanalytical factors on neurofilament concentrations in cerebrospinal fluid (CSF) in a reverse round-robin with 15 centers across Europe/U.S. METHODS: Samples from ALS and control patients (5/5 each center, n=150) were analyzed for phosphorylated neurofilament heavy chain (pNfH) and neurofilament light chain (NfL) at two laboratories. RESULTS: CSF pNfH was increased (p<0.05) in ALS in 10 out of 15 centers and NfL in 5 out of 12 centers. The coefficient of variation (CV%) of pNfH measurements between laboratories was 18.7 +/- 19.1%. We calculated a diagnostic cut-off of >568.5pg/mL for pNfH (sensitivity 78.7%, specificity 93.3%) and >1,431pg/mL for NfL (sensitivity 79.0%, specificity 86.4%). CONCLUSION: Values in ALS patients are already comparable between most centers, supporting eventual implementation into clinical routine. However, continuous quality control programs will be necessary for inclusion in the diagnostic work-up.
Subject headings and genre
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Jardel, Claude
(author)
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Salachas, Francois
(author)
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Lamari, Foudil
(author)
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Andersen, Peter M.Umeå universitet,Klinisk neurovetenskap(Swepub:umu)pean0001
(author)
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Bowser, Robert
(author)
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de Carvalho, Mamede
(author)
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Costa, Julia
(author)
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van Damme, Philip
(author)
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Gray, Elizabeth
(author)
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Grosskreutz, Julian
(author)
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Hernandez-Barral, Maria
(author)
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Herukka, Sanna-Kaisa
(author)
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Huss, Andre
(author)
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Jeromin, Andreas
(author)
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Kirby, Janine
(author)
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Kuzma-Kozakiewicz, Magdalena
(author)
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Amador, Maria del Mar
(author)
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Mora, Jesus S.
(author)
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Morelli, Claudia
(author)
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Muckova, Petra
(author)
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Petri, Susanne
(author)
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Poesen, Koen
(author)
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Rhode, Heidrun
(author)
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Rikardsson, Anna-KarinUmeå universitet,Klinisk neurovetenskap(Swepub:umu)anri0050
(author)
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Robberecht, Wim
(author)
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Rodriguez Mahillo, Ana I.
(author)
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Shaw, Pamela
(author)
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Silani, Vincenzo
(author)
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Steinacker, Petra
(author)
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Turner, Martin R.
(author)
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Tuzun, Erdem
(author)
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Yetimler, Berrak
(author)
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Ludolph, Albert C.
(author)
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Otto, Markus
(author)
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Umeå universitetKlinisk neurovetenskap
(creator_code:org_t)
Related titles
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In:Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration: Informa UK Limited17:5-6, s. 404-4132167-84212167-9223
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Oeckl, Patrick
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Jardel, Claude
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Salachas, Franco ...
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Lamari, Foudil
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Andersen, Peter ...
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Bowser, Robert
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de Carvalho, Mam ...
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Costa, Julia
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van Damme, Phili ...
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Gray, Elizabeth
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Grosskreutz, Jul ...
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Hernandez-Barral ...
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Herukka, Sanna-K ...
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Huss, Andre
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Jeromin, Andreas
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Kirby, Janine
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Kuzma-Kozakiewic ...
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Amador, Maria de ...
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Mora, Jesus S.
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Morelli, Claudia
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Muckova, Petra
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Petri, Susanne
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Poesen, Koen
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Rhode, Heidrun
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Rikardsson, Anna ...
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Robberecht, Wim
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Rodriguez Mahill ...
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Shaw, Pamela
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Silani, Vincenzo
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Steinacker, Petr ...
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Turner, Martin R ...
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Tuzun, Erdem
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Yetimler, Berrak
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Ludolph, Albert ...
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Otto, Markus
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- MEDICAL AND HEALTH SCIENCES
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Amyotrophic Late ...
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Umeå University