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Patient Heterogenei...
Patient Heterogeneity in Health Economic Decision Models for Chronic Obstructive Pulmonary Disease : Are Current Models Suitable to Evaluate Personalized Medicine?
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- Hoogendoorn, Martine (author)
- Erasmus University Rotterdam
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- Feenstra, Talitha L (author)
- National Institute for Public Health and the Environment (RIVM),University of Groningen
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- Asukai, Yumi (author)
- IMS Health Sweden AB
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- Briggs, Andrew H (author)
- University of Glasgow
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- Borg, Sixten (author)
- Lund University,Lunds universitet,Hälsoekonomi,Forskargrupper vid Lunds universitet,Health Economics,Lund University Research Groups,Evidera Ltd,IHE – The Swedish Institute for Health Economics
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- Dal Negro, Roberto W (author)
- National Center for Respiratory Pharmacoeconomics and Pharmacoepidemiology
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- Hansen, Ryan N (author)
- University of Washington
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- Jansson, Sven-Arne (author)
- Umeå University,Umeå universitet,Yrkes- och miljömedicin,The OLIN Unit
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- Leidl, Reiner (author)
- Helmholtz Zentrum München
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- Risebrough, Nancy (author)
- ICON Health Economics
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- Samyshkin, Yevgeniy (author)
- IMS Health Sweden AB
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- Wacker, Margarethe E (author)
- Helmholtz Zentrum München
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Rutten-van Mölken, Maureen P M H (author)
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: Value in Health. - : Elsevier BV. - 1098-3015 .- 1524-4733. ; 19:6, s. 800-810
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Abstract
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- OBJECTIVES: To assess how suitable current chronic obstructive pulmonary disease (COPD) cost-effectiveness models are to evaluate personalized treatment options for COPD by exploring the type of heterogeneity included in current models and by validating outcomes for subgroups of patients.METHODS: A consortium of COPD modeling groups completed three tasks. First, they reported all patient characteristics included in the model and provided the level of detail in which the input parameters were specified. Second, groups simulated disease progression, mortality, quality-adjusted life-years (QALYs), and costs for hypothetical subgroups of patients that differed in terms of sex, age, smoking status, and lung function (forced expiratory volume in 1 second [FEV1] % predicted). Finally, model outcomes for exacerbations and mortality for subgroups of patients were validated against published subgroup results of two large COPD trials.RESULTS: Nine COPD modeling groups participated. Most models included sex (seven), age (nine), smoking status (six), and FEV1% predicted (nine), mainly to specify disease progression and mortality. Trial results showed higher exacerbation rates for women (found in one model), higher mortality rates for men (two models), lower mortality for younger patients (four models), and higher exacerbation and mortality rates in patients with severe COPD (four models).CONCLUSIONS: Most currently available COPD cost-effectiveness models are able to evaluate the cost-effectiveness of personalized treatment on the basis of sex, age, smoking, and FEV1% predicted. Treatment in COPD is, however, more likely to be personalized on the basis of clinical parameters. Two models include several clinical patient characteristics and are therefore most suitable to evaluate personalized treatment, although some important clinical parameters are still missing.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Health Care Service and Management, Health Policy and Services and Health Economy (hsv//eng)
Keyword
- COPD
- model
- patient heterogeneity
- validation
- COPD
- model
- patient heterogeneity
- validation
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hoogendoorn, Mar ...
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Feenstra, Talith ...
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Asukai, Yumi
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Briggs, Andrew H
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Borg, Sixten
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Dal Negro, Rober ...
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show more...
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Hansen, Ryan N
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Jansson, Sven-Ar ...
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Leidl, Reiner
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Risebrough, Nanc ...
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Samyshkin, Yevge ...
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Wacker, Margaret ...
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Rutten-van Mölke ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Health Care Serv ...
- Articles in the publication
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Value in Health
- By the university
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Umeå University
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Lund University