Persistent brain infection and disease reactivation in relapsing fever borreliosis

Larsson, Christer, 1975- (author): Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Bergström

Andersson, Marie, 1962- (author): Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Bergström

Pelkonen, Jenni (author)

Guo, Betty (author): Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Bergström

Nordstrand, Annika (author): Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)

Bergström, Sven (author): Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Bergström

(creator_code:org_t)

Elsevier, 2006
2006
English.
In: Microbes and infection. - : Elsevier. - 1286-4579 .- 1769-714X. ; 8:8, s. 2213-2219

Related links:: http://www.ncbi.nlm....; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Abstract Subject headings

Relapsing fever, an infection caused by Borrelia spirochetes, is generally considered a transient, self-limiting disease in humans. The present study reveals that murine infection by Borrelia duttonii can be reactivated after an extended time as a silent infection in the brain, with no bacteria appearing in the blood and spirochete load comparable to the numbers in an infected tick. The host cerebral gene expression pattern is indistinguishable from that of uninfected animals, indicating that persistent bacteria are not recognized by the immune system nor cause noticeable tissue damage. Silent infection can be reactivated by immunosuppression, inducing spirochetemia comparable to that of initial densities. B. duttonii has never been found in any host except man and the tick vector. We therefore propose the brain to be a possible natural reservoir of the spirochete. The view of relapsing fever as an acute disease should be extended to include in some cases prolonged persistence, a feature characteristic of the related spirochetal infections Lyme disease and syphilis.

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)

By the author/editor: Larsson, Christe ...; Andersson, Marie ...; Pelkonen, Jenni; Guo, Betty; Nordstrand, Anni ...; Bergström, Sven

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Infectious Medic ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Microbiology in ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Immunology in th ...

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