CSF and plasma testosterone in attempted suicide

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Stefansson, Jon (author)

CSF and plasma testosterone in attempted suicide

Article/chapterEnglish2016

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Elsevier,2016
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LIBRIS-ID:oai:DiVA.org:umu-129801
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-129801URI
https://doi.org/10.1016/j.psyneuen.2016.08.009DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:134563881URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Very few studies have assessed testosterone levels in the cerebrospinal fluid in suicide attempters. Aggressiveness and impulsivity are common behavioural traits in suicide attempters. Dual-hormone serotonergic theory on human impulsive aggression implies high testosterone/cortisol ratio acting on the amygdala and low serotonin in the prefrontal cortex. Our aim was to examine the CSF and plasma testosterone levels in suicide attempters and in healthy volunteers. We also assessed the relationship between the testosterone/cortisol ratio, aggressiveness and impulsivity in suicide attempters. 28 medication-free suicide attempters and 19 healthy volunteers participated in the study. CSF and plasma testosterone sulfate and cortisol levels were assessed with specific radio-immunoassays. The Karolinska Scales of Personality was used to assess impulsivity and aggressiveness. All patients were followed up for cause of death. The mean follow-up period was 21 years. Male suicide attempters had higher CSF and plasma testosterone levels than age- matched male healthy volunteers. There were no significant differences in CSF testosterone levels in female suicide attempters and healthy female volunteers. Testosterone levels did not differ significantly in suicide victims compared to survivors. In male suicide attempters, the CSF testosterone/cortisol ratio showed a significant positive correlation with both impulsivity and aggressiveness. Higher CSF testosterone levels may be associated with attempted suicide in young men through association with both aggressiveness and impulsivity, a key endophenotype in young male suicide attempters.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
Suicide attempt
Testosterone
Impulsivity
Aggression
Cortisol

Added entries (persons, corporate bodies, meetings, titles ...)

Chatzittofis, AndreasKarolinska Institutet (author)
Nordstrom, PeterKarolinska Institutet (author)
Arver, StefanKarolinska Institutet (author)
Asberg, MarieKarolinska Institutet (author)
Jokinen, JussiKarolinska Institutet,Umeå universitet,Psykiatri,Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Stockholm, Sweden(Swepub:umu)jujo0022 (author)
Karolinska InstitutetPsykiatri (creator_code:org_t)

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In:Psychoneuroendocrinology: Elsevier74, s. 1-60306-45301873-3360

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By the author/editor: Stefansson, Jon; Chatzittofis, An ...; Nordstrom, Peter; Arver, Stefan; Asberg, Marie; Jokinen, Jussi

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

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