Elevated plasma homocysteine: cause or consequence of myocardial infarction?

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Hultdin, JohanUmeå universitet,Klinisk kemi (author)

Elevated plasma homocysteine : cause or consequence of myocardial infarction?

Article/chapterEnglish2004

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Wiley,2004
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LIBRIS-ID:oai:DiVA.org:umu-12981
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-12981URI
https://doi.org/10.1111/j.1365-2796.2004.01415.xDOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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OBJECTIVES: To determine whether a first myocardial infarction leads to increased plasma homocysteine concentrations and whether the association between homocysteine and myocardial infarction was greater at follow-up compared with baseline. DESIGN: A population-based, prospective, nested case-referent study. SETTING: Screening took place at the nearest health survey centre in northern Sweden. SUBJECTS: Of more than 36,000 persons screened, 78 developed a first myocardial infarction (average 18 months after sampling). Fifty of these had participated in a follow-up health survey (average 8(1/2) years between surveys) and were sex- and age-matched with 56 referents. MAIN OUTCOME MEASURES: Comparison of plasma homocysteine levels in case and referent subjects before and after development of a first myocardial infarction. RESULTS: No statistically significant difference was found between cases and referents regarding homocysteine at baseline or follow-up. Plasma homocysteine and plasma creatinine increased significantly, and plasma albumin decreased significantly over time. Conditional univariate logistic regression indicated that high homocysteine at follow-up but not baseline was associated with first myocardial infarction (OR 2.49; 95% CI: 1.03-6.02), but the relation disappeared in multivariate analyses including plasma creatinine and plasma albumin. High plasma creatinine remained associated with first myocardial infarction at both baseline (OR 2.94; 95% CI: 1.05-8.21) and follow-up (OR 3.38; 95% CI: 1.21-9.48). CONCLUSION: In this study, first myocardial infarction did not cause increased plasma homocysteine concentration.

Subject headings and genre

Case-Control Studies
Creatinine/blood
Female
Homocysteine/*blood
Humans
Male
Middle Aged
Myocardial Infarction/*blood
Prospective Studies
Risk Factors
Serum Albumin/analysis
Smoking/adverse effects

Added entries (persons, corporate bodies, meetings, titles ...)

Thøgersen, Ann MargrethUmeå universitet,Medicin (author)
Jansson, Jan-HåkanUmeå universitet,Medicin(Swepub:umu)jaja0006 (author)
Nilsson, T KUmeå universitet,Klinisk kemi (author)
Weinehall, LarsUmeå universitet,Epidemiologi och folkhälsovetenskap(Swepub:umu)lawe0001 (author)
Hallmans, GöranUmeå universitet,Näringsforskning(Swepub:umu)goha0001 (author)
Umeå universitetKlinisk kemi (creator_code:org_t)

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In:Journal of Internal Medicine: Wiley256:6, s. 491-4980954-68201365-2796

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