SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:umu-130062"
 

Search: onr:"swepub:oai:DiVA.org:umu-130062" > DNA methylome analy...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

DNA methylome analysis of acute lymphoblastic leukemia cells reveals stochastic de novo DNA methylation in CpG islands

Wahlberg, Per (author)
Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
Lundmark, Anders (author)
Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
Nordlund, Jessica (author)
Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
show more...
Busche, Stephan (author)
McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;Genome Quebec Innovat Ctr, Montreal, PQ, Canada.
Raine, Amanda (author)
Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
Tandre, Karolina (author)
Uppsala universitet,Reumatologi
Rönnblom, Lars (author)
Uppsala universitet,Reumatologi
Sinnett, Daniel (author)
St Justine Univ Hlth Ctr, Res Ctr, Montreal, PQ, Canada.;Univ Montreal, Dept Pediat, Montreal, PQ, Canada.
Forestier, Erik (author)
Umeå universitet,Medicinsk och klinisk genetik,Umea Univ, Dept Med Biosci, Umea, Sweden.
Pastinen, Tomi (author)
McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;Genome Quebec Innovat Ctr, Montreal, PQ, Canada.
Lönnerholm, Gudmar (author)
Uppsala universitet,Pediatrik
Syvänen, Ann-Christine (author)
Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
show less...
 (creator_code:org_t)
Future Medicine Ltd, 2016
2016
English.
In: Epigenomics. - : Future Medicine Ltd. - 1750-1911 .- 1750-192X. ; 8:10, s. 1367-1387
Related links:
https://umu.diva-por... (primary) (Raw object)
show more...
https://www.futureme...
https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.2...
https://urn.kb.se/re...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Aim: To identify regions of aberrant DNA methylation in acute lymphoblastic leukemia (ALL) cells of different subtypes on a genome-wide scale. Materials & methods: Whole-genome bisulfite sequencing (WGBS) was used to determine the DNA methylation levels in cells from four pediatric ALL patients of different subtypes. The findings were confirmed by 450k DNA methylation arrays in a large patient set. Results: Compared with mature B or T cells WGBS detected on average 82,000 differentially methylated regions per patient. Differentially methylated regions are enriched to CpG poor regions, active enhancers and transcriptional start sites. We also identified approximately 8000 CpG islands with variable intermediate DNA methylation that seems to occur as a result of stochastic de novo methylation. Conclusion: WGBS provides an unbiased view and novel insights into the DNA methylome of ALL cells.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Keyword

acute lymphoblastic leukemia
CpG islands
DNA methylation
epigenome
methylome
whole-genome bisulfite sequencing

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view