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Clonality of erythr...
Clonality of erythromycin resistance in Francisella tularensis
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Karlsson, Edvin (author)
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Golovliov, Igor (author)
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Lärkeryd, Adrian (author)
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Granberg, Malin (author)
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Larsson, Eva (author)
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Öhrman, Caroline (author)
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Niemcewicz, Marcin (author)
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Birdsell, Dawn (author)
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Wagner, David M. (author)
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Forsman, Mats (author)
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- Johansson, Anders (author)
- Umeå universitet,Klinisk bakteriologi,Molekylär Infektionsmedicin, Sverige (MIMS)
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(creator_code:org_t)
- 2016-06-21
- 2016
- English.
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In: Journal of Antimicrobial Chemotherapy. - : Oxford University Press (OUP). - 0305-7453 .- 1460-2091. ; 71:10, s. 2815-2823
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objectives: We analysed diverse strains of Francisella tularensis subsp. holarctica to assess if its division into biovars I and II is associated with specific mutations previously linked to erythromycin resistance and to determine the distribution of this resistance trait across this subspecies. Methods:Three-hundred and fourteen F. tularensis subsp. holarctica strains were tested for erythromycin susceptibility and whole-genome sequences for these strains were examined for SNPs in genes previously associated with erythromycin resistance. Each strain was assigned to a global phylogenetic framework using genome-wide canonical SNPs. The contribution of a specific SNP to erythromycin resistance was examined using allelic exchange. The geographical distribution of erythromycin-resistant F. tularensis strains was further investigated by literature search. Results:There was a perfect correlation between biovar II strains (erythromycin resistance) and the phylogenetic group B.12. Only B.12 strains had an AaEuroS -> aEuroSC SNP at position 2059 in the three copies of the rrl gene. Introducing 2059C into an rrl gene of an erythromycin-susceptible F. tularensis strain resulted in resistance. An additional 1144 erythromycin-resistant strains were identified from the scientific literature, all of them from Eurasia. Conclusions:Erythromycin resistance in F. tularensis is caused by an A2059C rrl gene mutation, which exhibits a strictly clonal inheritance pattern found only in phylogenetic group B.12. This group is an extremely successful clone, representing the most common type of F. tularensis throughout Eurasia.
Subject headings
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Karlsson, Edvin
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Golovliov, Igor
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Lärkeryd, Adrian
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Granberg, Malin
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Larsson, Eva
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Öhrman, Caroline
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show more...
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Niemcewicz, Marc ...
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Birdsell, Dawn
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Wagner, David M.
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Forsman, Mats
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Johansson, Ander ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
- Articles in the publication
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Journal of Antim ...
- By the university
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Umeå University