Electronic cigarettes increase endothelial progenitor cells in the blood of healthy volunteers

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Antoniewicz, LukaszKarolinska Institutet (author)

Electronic cigarettes increase endothelial progenitor cells in the blood of healthy volunteers

Article/chapterEnglish2016

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Elsevier BV,2016
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LIBRIS-ID:oai:DiVA.org:umu-130236
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-130236URI
https://doi.org/10.1016/j.atherosclerosis.2016.09.064DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:134810705URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Background and aims: The use of electronic cigarettes is increasing dramatically on a global scale and its effects on human health remain uncertain. In the present study, we measured endothelial progenitor cells (EPCs) and microvesicles (MVs) in healthy young volunteers following short-term exposure to inhalation of e-cigarette vapor (ECV) to determine vascular changes.Methods: Sixteen healthy seldom smokers were randomized into two groups either exposed or not exposed to 10 puffs of ECV for 10 min, in a crossover design. Blood samples were obtained at baseline and 1, 4 and 24 h following exposure. EPCs (CD34 + CD309) and MVs were analyzed by flow cytometry. MVs were phenotyped according to origin (platelet (CD41), endothelial (CD144), leukocytes (CD45), monocytes (CD14)) and nuclear content (SYTO 13 dye). In addition, expression of inflammation markers such P-selectin (CD62P), E-selectin (CD62E), CD40-ligand (CD154) and HMGB1 was investigated. Fractional exhaled nitric oxide (FeNO) was also measured at baseline and after 24 h.Results: EPC levels in blood were significantly increased 1 h following exposure to ECV and returned to baseline values after 24 h. Only E-selectin positive MVs (endothelial origin) were slightly elevated (p < 0.038). FeNO was unaffected by exposure to ECV. Conclusions: In healthy volunteers, ten puffs of e-cigarette vapor inhalation caused an increase in EPCs. This increase was of the same magnitude as following smoking of one traditional cigarette, as we previously demonstrated. Taken together, these results may represent signs of possible vascular changes after short e-cigarette inhalation. Further studies analyzing potential cardiovascular health effects are critical as the e-cigarette market continues to burgeon.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
Electronic cigarette
E-cigarette
Endothelial progenitor cells
Microvesicles

Added entries (persons, corporate bodies, meetings, titles ...)

Bosson, Jenny A.Umeå universitet,Lungmedicin(Swepub:umu)jebo0004 (author)
Kuhl, JeanetteKarolinska Institutet (author)
Abdel-Halim, Samy M. (author)
Kiessling, AnnaKarolinska Institutet (author)
Mobarrez, FariborzKarolinska Institutet (author)
Lundback, MagnusKarolinska Institutet (author)
Karolinska InstitutetLungmedicin (creator_code:org_t)

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In:Atherosclerosis: Elsevier BV255, s. 179-1850021-91501879-1484

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Respiratory Medi ...

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By the university: Umeå University; Karolinska Institutet

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