C-11-Acetate-PET/CT Compared to Tc-99m-HDP Bone Scintigraphy in Primary Staging of High-risk Prostate Cancer

Strandberg, Sara (author): Umeå universitet,Institutionen för strålningsvetenskaper

Karlsson, Camilla Thellenberg (author): Umeå universitet,Institutionen för strålningsvetenskaper

Ögren, Mattias (author): Umeå universitet,Institutionen för strålningsvetenskaper

Axelsson, Jan (author): Umeå universitet,Institutionen för strålningsvetenskaper

Riklund, Katrine (author): Umeå universitet,Institutionen för strålningsvetenskaper

(creator_code:org_t)

International Institute of Anticancer Research, 2016
2016
English.
In: Anticancer Research. - : International Institute of Anticancer Research. - 0250-7005 .- 1791-7530. ; 36:12, s. 6475-6479

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.2...; show less...

Abstract Subject headings

Aim: The aim of this study was to evaluate the detection rate of bone metastases and the added value of C-11-acetate (ACE) positron-emission tomography/computed tomography (PET/CT) compared to bone scintigraphy (BS) in high-risk prostate cancer (PC).Materials and Methods: A total of 66 untreated patients with high-risk PC with ACE-PET/CT and planar BS findings within 3 months of each other were retrospectively enrolled. Findings were compared and verified with follow-up data after an average of 26 months.Results: The rate of detection of bone metastases was superior with ACE-PET/CT compared to BS (p<0.01). Agreement between the methods and between BS and follow-up was moderate (Cohen's kappa coefficient of 0.64 and 0.66, respectively). Agreement between ACE-PET/CT and follow-up was excellent (kappa coefficient of 0.95). Therapy was changed in 11% of patients due to ACE-PET/CT results.Conclusion: ACE-PET/CT performed better than planar BS in detection of bone metastases in high-risk PC. ACE-PET/CT findings influenced clinical management.

By the author/editor: Strandberg, Sara; Karlsson, Camill ...; Ögren, Mattias; Axelsson, Jan; Riklund, Katrine

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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