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Diesel exhaust expo...
Diesel exhaust exposure enhances the expression of IL-13 in the bronchial epithelium of healthy subjects.
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- Pourazar, Jamshid (author)
- Umeå universitet,Lungmedicin
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Frew, Anthony J (author)
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- Blomberg, Anders (author)
- Umeå universitet,Lungmedicin
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- Helleday, Ragnberth (author)
- Umeå universitet,Lungmedicin
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Kelly, Frank J (author)
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Wilson, Susan (author)
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- Sandström, Thomas (author)
- Umeå universitet,Lungmedicin
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(creator_code:org_t)
- Elsevier BV, 2004
- 2004
- English.
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In: Respiratory Medicine. - : Elsevier BV. - 0954-6111 .- 1532-3064. ; 98:9, s. 821-825
- Related links:
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http://www.ncbi.nlm....
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http://www.resmedjou...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Epidemiological studies have demonstrated adverse health effects of environmental pollution. Diesel exhaust (DE) is an important contributor to ambient particulate matter pollution. DE exposure has been shown to induce a pronounced inflammatory response in the airways, with an enhanced epithelial expression of IL-8, and Gro-α in healthy subjects. The present investigation was aimed to further characterise the epithelial response to DE in vivo, with particular reference to possible TH2 response, in non-atopic healthy subjects. To determine this response, 15 healthy, non-atopic non-smoking subjects with normal lung function were exposed to DE (PM10 300 μg/m3) and filtered air during 1 h on two separate randomised occasions. Bronchoscopy sampling of bronchial mucosal biopsies was performed 6 h after exposure. Immunohistochemical staining were performed using mAb for IL-10, IL-13 and IL-18 expression. DE exposure induced a significant increase in the expression of IL-13 in the bronchial epithelium cells, 2.1 (1.35–4.88) Md (Q1–Q3) vs. air 0.94 (0.53–1.23); P=0.009. No significant changes were seen in IL-10 and IL-18 expression. This finding suggests an TH2-inflammatory response in the airways of non-atopic healthy individuals.
Keyword
- Adult
- Air Pollutants/*toxicity
- Bronchi/*immunology
- Environmental Exposure/adverse effects
- Epithelium/immunology
- Female
- Humans
- Immunohistochemistry/methods
- Interleukin-13/*analysis
- Male
- Respiratory Mucosa/immunology
- T-Lymphocytes; Helper-Inducer/immunology
- Vehicle Emissions/*toxicity
Publication and Content Type
- ref (subject category)
- art (subject category)
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