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Genome-wide analyse...
Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders
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Lo, Min-Tzu (author)
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Hinds, David A. (author)
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Tung, Joyce Y. (author)
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Franz, Carol (author)
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Fan, Chun-Chieh (author)
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Wang, Yunpeng (author)
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Smeland, Olav B. (author)
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Schork, Andrew (author)
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Holland, Dominic (author)
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- Kauppi, Karolina (author)
- Umeå universitet,Institutionen för strålningsvetenskaper,Department of Radiology, University of California, San Diego, La Jolla, California, USA
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Sanyal, Nilotpal (author)
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Escott-Price, Valentina (author)
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Smith, Daniel J. (author)
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O'Donovan, Michael (author)
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Stefansson, Hreinn (author)
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Bjornsdottir, Gyda (author)
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Thorgeirsson, Thorgeir E. (author)
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Stefansson, Kari (author)
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McEvoy, Linda K. (author)
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Dale, Anders M. (author)
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Andreassen, Ole A. (author)
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Chen, Chi-Hua (author)
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(creator_code:org_t)
- 2016-12-05
- 2017
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 49:1, s. 152-156
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https://urn.kb.se/re...
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Abstract
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- Personality is influenced by genetic and environmental factors(1) and associated with mental health. However, the underlying genetic determinants are largely unknown. We identified six genetic loci, including five novel loci(2,3), significantly associated with personality traits in a meta-analysis of genome-wide association studies (N = 123,132-260,861). Of these genome-wide significant loci, extraversion was associated with variants in WSCD2 and near PCDH15, and neuroticism with variants on chromosome 8p23.1 and in L3MBTL2. We performed a principal component analysis to extract major dimensions underlying genetic variations among five personality traits and six psychiatric disorders (N = 5,422-18,759). The first genetic dimension separated personality traits and psychiatric disorders, except that neuroticism and openness to experience were clustered with the disorders. High genetic correlations were found between extraversion and attention-deficit- hyperactivity disorder (ADHD) and between openness and schizophrenia and bipolar disorder. The second genetic dimension was closely aligned with extraversion-introversion and grouped neuroticism with internalizing psychopathology (e.g., depression or anxiety).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lo, Min-Tzu
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Hinds, David A.
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Tung, Joyce Y.
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Franz, Carol
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Fan, Chun-Chieh
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Wang, Yunpeng
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show more...
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Smeland, Olav B.
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Schork, Andrew
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Holland, Dominic
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Kauppi, Karolina
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Sanyal, Nilotpal
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Escott-Price, Va ...
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Smith, Daniel J.
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O'Donovan, Micha ...
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Stefansson, Hrei ...
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Bjornsdottir, Gy ...
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Thorgeirsson, Th ...
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Stefansson, Kari
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McEvoy, Linda K.
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Dale, Anders M.
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Andreassen, Ole ...
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Chen, Chi-Hua
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Nature Genetics
- By the university
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Umeå University