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Biomarkers of folat...
Biomarkers of folate and vitamin B12 and breast cancer risk : report from the EPIC cohort
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Matejcic, M. (author)
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de Batlle, J. (author)
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Ricci, C. (author)
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Biessy, C. (author)
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Perrier, F. (author)
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Huybrechts, I. (author)
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- Weiderpass, E. (author)
- Karolinska Institutet
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Boutron-Ruault, M. C. (author)
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Cadeau, C. (author)
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His, M. (author)
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Cox, D. G. (author)
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Boeing, H. (author)
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Fortner, R. T. (author)
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Kaaks, R. (author)
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Lagiou, P. (author)
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Trichopoulou, A. (author)
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Benetou, V. (author)
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Tumino, R. (author)
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Panico, S. (author)
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Sieri, S. (author)
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Palli, D. (author)
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Ricceri, F. (author)
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Bueno-de-Mesquita, H. B(as) (author)
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Skeie, G. (author)
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Amiano, P. (author)
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Sanchez, M. J. (author)
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Chirlaque, M. D. (author)
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Barricarte, A. (author)
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Quiros, J. R. (author)
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Buckland, G. (author)
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van Gils, C. H. (author)
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Peeters, P. H. (author)
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Key, T. J. (author)
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Riboli, E. (author)
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- Gylling, Björn (author)
- Umeå universitet,Patologi
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Zeleniuch-Jacquotte, A. (author)
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Gunter, M. J. (author)
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Romieu, I. (author)
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Chajes, V. (author)
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(creator_code:org_t)
- 2017-01-27
- 2017
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 140:6, s. 1246-1259
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Epidemiological studies have reported inconsistent findings for the association between B vitamins and breast cancer (BC) risk. We investigated the relationship between biomarkers of folate and vitamin B12 and the risk of BC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Plasma concentrations of folate and vitamin B12 were determined in 2,491 BC cases individually matched to 2,521 controls among women who provided baseline blood samples. Multivariable logistic regression models were used to estimate odds ratios by quartiles of either plasma B vitamin. Subgroup analyses by menopausal status, hormone receptor status of breast tumors (estrogen receptor [ER], progesterone receptor [PR] and human epidermal growth factor receptor 2 [HER2]), alcohol intake and MTHFR polymorphisms (677C > T and 1298A > C) were also performed. Plasma levels of folate and vitamin B12 were not significantly associated with the overall risk of BC or by hormone receptor status. A marginally positive association was found between vitamin B12 status and BC risk in women consuming above the median level of alcohol (ORQ4-Q1=1.26; 95% CI 1.00-1.58; P-trend=0.05). Vitamin B12 status was also positively associated with BC risk in women with plasma folate levels below the median value (ORQ4-Q1=1.29; 95% CI 1.02-162; P-trend=0.03). Overall, folate and vitamin B12 status was not clearly associated with BC risk in this prospective cohort study. However, potential interactions between vitamin B12 and alcohol or folate on the risk of BC deserve further investigation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- plasma biomarkers
- folate
- vitamin B12
- alcohol
- hormone receptor status
- MTHFR polymorphism
- east cancer
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Matejcic, M.
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de Batlle, J.
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Ricci, C.
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Biessy, C.
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Perrier, F.
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Huybrechts, I.
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show more...
-
Weiderpass, E.
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Boutron-Ruault, ...
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Cadeau, C.
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His, M.
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Cox, D. G.
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Boeing, H.
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Fortner, R. T.
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Kaaks, R.
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Lagiou, P.
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Trichopoulou, A.
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Benetou, V.
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Tumino, R.
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Panico, S.
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Sieri, S.
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Palli, D.
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Ricceri, F.
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Bueno-de-Mesquit ...
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Skeie, G.
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Amiano, P.
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Sanchez, M. J.
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Chirlaque, M. D.
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Barricarte, A.
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Quiros, J. R.
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Buckland, G.
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van Gils, C. H.
-
Peeters, P. H.
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Key, T. J.
-
Riboli, E.
-
Gylling, Björn
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Zeleniuch-Jacquo ...
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Gunter, M. J.
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Romieu, I.
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Chajes, V.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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Umeå University
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Karolinska Institutet