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Epigenetic changes ...
Epigenetic changes as prognostic predictors in endometrial carcinomas
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- Farkas, Sanja A., 1983- (author)
- Örebro universitet,Institutionen för hälsovetenskaper,Region Örebro län,Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden
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- Sorbe, Bengt G., 1947- (author)
- Örebro universitet,Institutionen för hälsovetenskaper,Region Örebro län,Department of Oncology, Örebro University Hospital, Örebro, Sweden
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- Nilsson, Torbjörn K. (author)
- Umeå universitet,Klinisk kemi,Department of Medical Biosciences/Clinical Chemistry, Umeå University, Umeå, Sweden
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(creator_code:org_t)
- 2016-12-29
- 2017
- English.
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In: Epigenetics. - : Informa UK Limited. - 1559-2294 .- 1559-2308. ; 12:1, s. 19-26
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Abstract
Subject headings
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- Endometrial carcinoma is one of the most frequent gynecological malignancies of the female. The diagnostic and prognostic markers for the high-risk subgroups with unfavorable prognosis are under intense debate worldwide, and, therefore, the aim of this study was to identify new potential DNA methylation markers for the high-risk groups. We used the Illumina Infinium HumanMethylation450 BeadChip to analyze the DNA methylation pattern and investigated its association with clinicopathological features important for defining the high-risk (FIGO-grade 3) and low-risk (FIGO-grade 1) groups of patients with endometrial cancer (n = 31 and n = 39, respectively). We identified specific DNA methylation signature in high-risk endometrial tumors, and potential molecular biomarker genes (TBX2, CHST11, and NID2) associated with unfavorable clinical predictive and prognostic factors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Keyword
- DNA methylation
- endometrial cancer
- FIGO grade
- prognosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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