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  • Lundberg, IdaUmeå universitet,Patologi (author)

MicroRNA expression in KRAS- and BRAF-mutated colorectal cancers

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • International Institute of Anticancer Research,2018
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:umu-133409
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133409URI
  • https://doi.org/10.21873/anticanres.12272DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • Originally included in thesis in manuscript form
  • Background/Aim: KRAS and BRAF are two genes commonly mutated in colorectal cancer (CRC). Even though BRAF is a downstream target of KRAS in the MAPK signalling pathway, KRAS- and BRAF-mutated CRCs are found to display several different clinical and histopathological features. We investigated whether a differential expression of microRNAs (miRNAs) could explain the clinicopathological differences seen between KRAS-and BRAF-mutated CRCs.Materials and Methods: Using a PCR array, we analyzed the expression of 84 different miRNAs in CRC cell lines wild-type in KRAS and BRAF, or mutated in KRAS or BRAF.Results: Ten miRNAs were selected for further analyses in tumor tissue specimens (let-7a, let-7i, miR-10a, miR-10b, miR-31, miR-100, miR-181a, miR-181b, miR-372, and miR-373). BRAF-mutated tumors were found to express significantly higher levels of miR-31 as well as significantly lower levels of miR-373, compared to wild-type tumors.Conclusion: Our results suggest that KRAS and BRAF-mutated CRCs may have different miRNA signatures compared to CRC tumors wild-type in KRAS and BRAF. However, no difference in expression levels between KRAS-and BRAF-mutated tumors was evident for the miRNAs analyzed in this study.

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  • Wikberg, Maria L.Umeå universitet,Patologi(Swepub:umu)mahe0061 (author)
  • Ljuslinder, IngridUmeå universitet,Onkologi(Swepub:umu)inlj0001 (author)
  • Li, XingruUmeå universitet,Patologi(Swepub:umu)xili0010 (author)
  • Myte, RobinUmeå universitet,Onkologi(Swepub:umu)romy0001 (author)
  • Zingmark, CarlUmeå universitet,Patologi(Swepub:umu)cazi0001 (author)
  • Löfgren-Burström, AnnaUmeå universitet,Patologi(Swepub:umu)anlo0002 (author)
  • Edin, SofiaUmeå universitet,Patologi(Swepub:umu)soed0001 (author)
  • Palmqvist, RichardUmeå universitet,Patologi(Swepub:umu)ripa0001 (author)
  • Umeå universitetPatologi (creator_code:org_t)

Related titles

  • In:Anticancer Research: International Institute of Anticancer Research38:2, s. 677-6830250-70051791-7530

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