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Inflammatory Cytoki...
Inflammatory Cytokines and Lung Cancer Risk in 3 Prospective Studies
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Brenner, Darren R. (author)
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Fanidi, Anouar (author)
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- Grankvist, Kjell (author)
- Umeå universitet,Klinisk kemi
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Muller, David C. (author)
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Brennan, Paul (author)
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Manjer, Jonas (author)
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Byrnes, Graham (author)
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Hodge, Allison (author)
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Severi, Gianluca (author)
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Giles, Graham G. (author)
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- Johansson, Mikael (author)
- Umeå universitet,Institutionen för strålningsvetenskaper
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Johansson, Mattias (author)
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(creator_code:org_t)
- 2016-12-20
- 2017
- English.
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In: American Journal of Epidemiology. - : OXFORD UNIV PRESS INC. - 0002-9262 .- 1476-6256. ; 185:2, s. 86-95
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- To further investigate the role of inflammation in lung carcinogenesis, we evaluated associations between proinflammatory cytokines and lung cancer risk. We conducted a case-control study nested within 3 prospective cohort studies-the Melbourne Collaborative Cohort Study (1990-1994), the Malm Diet and Cancer Study (1991-1996), and the Northern Sweden Health and Disease Study (initiated in 1985)-involving 807 incident lung cancer cases and 807 smoking-matched controls. Conditional logistic regression models adjusting for serum cotinine concentrations were used to estimate odds ratios for lung cancer risk associated with concentrations of interleukin (IL)-1 beta, IL-2, IL-6, IL-8, IL-10, IL-12, interferon., tumor necrosis factor a, and granulocyte-macrophage colony-stimulating factor. We observed a higher lung cancer risk for participants with elevated concentrations of IL-6 and IL-8. These associations seemed to be stronger among former smokers (for fourth quartile vs. first quartile, odds ratio (OR) = 2.70, 95% confidence interval (CI): 1.55, 4.70) and current smokers (OR = 1.99, 95% CI: 1.15, 3.44) for IL-6 and among former smokers (OR = 2.83, 95% CI: 1.18, 6.75) and current smokers (OR = 1.30, 95% CI: 0.69, 2.44) for IL-8. No notable associations were observed among never smokers. Risk associations with IL-6 and IL-8 were observed for blood samples taken close to diagnosis (< 5 years) as well as more than 15 years postdiagnosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- cohort studies
- cytokines
- inflammation
- lung neoplasms
- risk factors
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Brenner, Darren ...
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Fanidi, Anouar
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Grankvist, Kjell
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Muller, David C.
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Brennan, Paul
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Manjer, Jonas
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show more...
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Byrnes, Graham
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Hodge, Allison
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Severi, Gianluca
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Giles, Graham G.
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Johansson, Mikae ...
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Johansson, Matti ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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American Journal ...
- By the university
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Umeå University