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Updated European As...
Updated European Association of Urology Guidelines Regarding Adjuvant Therapy for Renal Cell Carcinoma
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- Bex, Axel (author)
- Netherlands Cancer Institute
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- Albiges, Laurence (author)
- Institut Gustave Roussy
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- Ljungberg, Börje (author)
- Umeå University,Umeå universitet,Urologi och andrologi
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- Bensalah, Karim (author)
- University of Rennes I
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- Dabestani, Saeed (author)
- Lund University,Lunds universitet,Urologi,Forskargrupper vid Lunds universitet,Urology,Lund University Research Groups,Skåne University Hospital
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- Giles, Rachel H. (author)
- University Medical Center Utrecht
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- Hofmann, Fabian (author)
- Sunderby Hospital
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- Hora, Milan (author)
- Charles University in Prague
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- Kuczyk, Markus A. (author)
- Hannover Medical School
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- Lam, Thomas B. (author)
- University of Aberdeen
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- Marconi, Lorenzo (author)
- University Hospital of Coimbra
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- Merseburger, Axel S. (author)
- University Medical Center Schleswig-Holstein
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- Staehler, Michael (author)
- Ludwig-Maximilian University of Munich
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- Volpe, Alessandro (author)
- University of Eastern Piedmont
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- Powles, Thomas (author)
- Queen Mary University
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: European Urology. - : Elsevier BV. - 0302-2838 .- 1873-7560. ; 71:5, s. 719-722
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- The European Association of Urology Renal Cell Carcinoma (RCC) guidelines panel updated their recommendation on adjuvant therapy in unfavourable, clinically nonmetastatic RCC following the recently reported results of a second randomised controlled phase 3 trial comparing 1-yr sunitinib to placebo for high-risk RCC after nephrectomy (S-TRAC). On the basis of conflicting results from the two available studies, the panel rated the quality of the evidence, the harm-to-benefit ratio, patient preferences, and costs. Finally, the panel, including representatives from a patient advocate group (International Kidney Cancer Coalition) voted and reached a consensus to not recommend adjuvant therapy with sunitinib for patients with high-risk RCC after nephrectomy. Patient summary: In two studies, sunitinib was given for 1 yr and compared to no active treatment (placebo) in patients who had their kidney tumour removed and who had a high risk of cancer coming back after surgery. Although one study demonstrated that 1 yr of sunitinib therapy resulted in a 1.2-yr longer time before the disease recurred, the other study did not show a benefit and it has not been shown that patients live longer. Despite having been diagnosed with high-risk disease, many patients remain without recurrence, and the side effects of sunitinib are high. Therefore, the panel members, including patient representatives, do not recommend sunitinib after tumour removal in these patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Renal cell cancer
- Management
- Adjuvant
- Sunitinib
- Sorafenib
- Guidelines
- Adjuvant
- Guidelines
- Management
- Renal cell cancer
- Sorafenib
- Sunitinib
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Bex, Axel
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Albiges, Laurenc ...
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Ljungberg, Börje
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Bensalah, Karim
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Dabestani, Saeed
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Giles, Rachel H.
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show more...
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Hofmann, Fabian
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Hora, Milan
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Kuczyk, Markus A ...
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Lam, Thomas B.
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Marconi, Lorenzo
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Merseburger, Axe ...
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Staehler, Michae ...
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Volpe, Alessandr ...
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Powles, Thomas
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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European Urology
- By the university
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Umeå University
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Lund University