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  • Makarova, Kira S (author)

An updated evolutionary classification of CRISPR-Cas systems

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2015-09-28
  • Springer Science and Business Media LLC,2015
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-133869
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133869URI
  • https://doi.org/10.1038/nrmicro3569DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The evolution of CRISPR-cas loci, which encode adaptive immune systems in archaea and bacteria, involves rapid changes, in particular numerous rearrangements of the locus architecture and horizontal transfer of complete loci or individual modules. These dynamics complicate straightforward phylogenetic classification, but here we present an approach combining the analysis of signature protein families and features of the architecture of cas loci that unambiguously partitions most CRISPR-cas loci into distinct classes, types and subtypes. The new classification retains the overall structure of the previous version but is expanded to now encompass two classes, five types and 16 subtypes. The relative stability of the classification suggests that the most prevalent variants of CRISPR-Cas systems are already known. However, the existence of rare, currently unclassifiable variants implies that additional types and subtypes remain to be characterized.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Wolf, Yuri I (author)
  • Alkhnbashi, Omer S (author)
  • Costa, Fabrizio (author)
  • Shah, Shiraz A (author)
  • Saunders, Sita J (author)
  • Barrangou, Rodolphe (author)
  • Brouns, Stan J J (author)
  • Charpentier, Emmanuelle,1968-Department of Regulation in Infection, Max Planck Institute for Infection Biology,Charpentier(Swepub:umu)emch0006 (author)
  • Haft, Daniel H (author)
  • Horvath, Philippe (author)
  • Moineau, Sylvain (author)
  • Mojica, Francisco J M (author)
  • Terns, Rebecca M (author)
  • Terns, Michael P (author)
  • White, Malcolm F (author)
  • Yakunin, Alexander F (author)
  • Garrett, Roger A (author)
  • van der Oost, John (author)
  • Backofen, Rolf (author)
  • Koonin, Eugene V (author)
  • Department of Regulation in Infection, Max Planck Institute for Infection BiologyCharpentier (creator_code:org_t)

Related titles

  • In:Nature Reviews Microbiology: Springer Science and Business Media LLC13:11, s. 722-7361740-15261740-1534

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