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Vitamin B-6 and col...
Vitamin B-6 and colorectal cancer risk : a prospective population-based study using 3 distinct plasma markers of vitamin B-6 status
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- Gylling, Björn (author)
- Umeå universitet,Patologi
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- Myte, Robin (author)
- Umeå universitet,Onkologi
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- Schneede, Jørn (author)
- Umeå universitet,Farmakologi
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- Hallmans, Göran, 1947- (author)
- Umeå universitet,Enheten för biobanksforskning
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- Häggstrom, Jenny (author)
- Umeå universitet,Statistik
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- Johansson, Ingegerd (author)
- Umeå universitet,Institutionen för odontologi
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Ulvik, Arve (author)
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Ueland, Per M. (author)
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- Van Guelpen, Bethany (author)
- Umeå universitet,Onkologi
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- Palmqvist, Richard (author)
- Umeå universitet,Patologi
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 105:4, s. 897-904
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
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- Background: Higher plasma concentrations of the vitamin B-6 marker pyridoxal 5#-phosphate (PLP) have been associated with reduced colorectal cancer (CRC) risk. Inflammatory processes, including vitamin B-6 catabolism, could explain such findings. Objective: We investigated 3 biomarkers of vitamin B-6 status in relation to CRC risk. Design: This was a prospective case-control study of 613 CRC cases and 1190 matched controls nested within the Northern Sweden Health and Disease Study (n = 114,679). Participants were followed from 1985 to 2009, and the median follow-up from baseline to CRC diagnosis was 8.2 y. PLP, pyridoxal, pyridoxic acid (PA), 3-hydroxykynurenine, and xanthurenic acids (XAs) were measured in plasma with the use of liquid chromatography-tandem mass spectrometry. We calculated relative and absolute risks of CRC for PLP and the ratios 3-hydroxykynurenine: XA (HK: XA), an inverse marker of functional vitamin B-6 status, and PA:(PLP + pyridoxal) (PAr), a marker of inflammation and oxidative stress and an inverse marker of vitamin B-6 status. Results: Plasma PLP concentrations were associated with a reduced CRC risk for the third compared with the first quartile and for PLP sufficiency compared with deficiency [OR: 0.60 (95% CI: 0.44, 0.81) and OR: 0.55 (95% CI: 0.37, 0.81), respectively]. HK: XA and PAr were both associated with increased CRC risk [OR: 1.48 (95% CI: 1.08, 2.02) and OR: 1.50 (95% CI: 1.10, 2.04), respectively] for the fourth compared with the first quartile. For HK: XA and PAr, the findings were mainly observed in study participants with,10.5 y of follow-up between sampling and diagnosis. Conclusions: Vitamin B-6 deficiency as measured by plasma PLP is associated with a clear increase in CRC risk. Furthermore, our analyses of novel markers of functional vitamin B-6 status and vitamin B-6-associated oxidative stress and inflammation suggest a role in tumor progression rather than initiation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Gylling, Björn
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Myte, Robin
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Schneede, Jørn
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Hallmans, Göran, ...
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Häggstrom, Jenny
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Johansson, Ingeg ...
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show more...
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Ulvik, Arve
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Ueland, Per M.
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Van Guelpen, Bet ...
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Palmqvist, Richa ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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American Journal ...
- By the university
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Umeå University