Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

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Melin, Beatrice S.Umeå universitet,Institutionen för strålningsvetenskaper (author)

Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

Article/chapterEnglish2017

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2017-03-27
Springer Science and Business Media LLC,2017
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LIBRIS-ID:oai:DiVA.org:umu-135267
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-135267URI
https://doi.org/10.1038/ng.3823DOI

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Language:English
Summary in:English

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Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 x 10(-9), odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 x 10(-10), OR = 1.24), 16p13.3 (rs2562152; P = 1.93 x 10-8, OR = 1.21), 16q12.1 (rs10852606; P = 1.29 x 10(-11), OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 x 10(-10), OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 x 10(-9), OR = 1.19), 1q44 (rs12076373; P = 2.63 x 10(-10), OR = 1.23), 2q33.3 (rs7572263; P = 2.18 x 10(-10), OR = 1.20), 3p14.1 (rs11706832; P = 7.66 x 10(-9), OR = 1.15), 10q24.33 (rs11598018; P = 3.39 x 10-8, OR = 1.14), 11q21 (rs7107785; P = 3.87 x 10(-10), OR = 1.16), 14q12 (rs10131032; P = 5.07 x 10(-11), OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 x 10(-9), OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.

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Barnholtz-Sloan, Jill S. (author)
Wrensch, Margaret R. (author)
Johansen, Christoffer (author)
Il'yasova, Dora (author)
Kinnersley, Ben (author)
Ostrom, Quinn T. (author)
Labreche, Karim (author)
Chen, Yanwen (author)
Armstrong, Georgina (author)
Liu, Yanhong (author)
Eckel-Passow, Jeanette E. (author)
Decker, Paul A. (author)
Labussiere, Marianne (author)
Idbaih, Ahmed (author)
Hoang-Xuan, Khe (author)
Di Stefano, Anna-Luisa (author)
Mokhtari, Karima (author)
Delattre, Jean-Yves (author)
Broderick, Peter (author)
Galan, Pilar (author)
Gousias, Konstantinos (author)
Schramm, Johannes (author)
Schoemaker, Minouk J. (author)
Fleming, Sarah J. (author)
Herms, Stefan (author)
Heilmann, Stefanie (author)
Noethen, Markus M. (author)
Wichmann, Heinz-Erich (author)
Schreiber, Stefan (author)
Swerdlow, Anthony (author)
Lathrop, Mark (author)
Simon, Matthias (author)
Sanson, Marc (author)
Andersson, UlrikaUmeå universitet,Institutionen för strålningsvetenskaper(Swepub:umu)ulan0002 (author)
Rajaraman, Preetha (author)
Chanock, Stephen (author)
Linet, Martha (author)
Wang, Zhaoming (author)
Yeager, Meredith (author)
Wiencke, John K. (author)
Hansen, Helen (author)
Mccoy, Lucie (author)
Rice, Terri (author)
Kosel, Matthew L. (author)
Sicotte, Hugues (author)
Amos, Christopher I. (author)
Bernstein, Jonine L. (author)
Davis, Faith (author)
Lachance, Dan (author)
Lau, Ching (author)
Merrell, Ryan T. (author)
Shildkraut, Joellen (author)
Ali-Osman, Francis (author)
Sadetzki, Siegal (author)
Scheurer, Michael (author)
Shete, Sanjay (author)
Lai, Rose K. (author)
Claus, Elizabeth B. (author)
Olson, Sara H. (author)
Jenkins, Robert B. (author)
Houlston, Richard S. (author)
Bondy, Melissa L. (author)
Umeå universitetInstitutionen för strålningsvetenskaper (creator_code:org_t)

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In:Nature Genetics: Springer Science and Business Media LLC49:5, s. 789-7941061-40361546-1718

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By the author/editor: Melin, Beatrice ...; Barnholtz-Sloan, ...; Wrensch, Margare ...; Johansen, Christ ...; Il'yasova, Dora; Kinnersley, Ben; show more...; Ostrom, Quinn T.; Labreche, Karim; Chen, Yanwen; Armstrong, Georg ...; Liu, Yanhong; Eckel-Passow, Je ...; Decker, Paul A.; Labussiere, Mari ...; Idbaih, Ahmed; Hoang-Xuan, Khe; Di Stefano, Anna ...; Mokhtari, Karima; Delattre, Jean-Y ...; Broderick, Peter; Galan, Pilar; Gousias, Konstan ...; Schramm, Johanne ...; Schoemaker, Mino ...; Fleming, Sarah J ...; Herms, Stefan; Heilmann, Stefan ...; Noethen, Markus ...; Wichmann, Heinz- ...; Schreiber, Stefa ...; Swerdlow, Anthon ...; Lathrop, Mark; Simon, Matthias; Sanson, Marc; Andersson, Ulrik ...; Rajaraman, Preet ...; Chanock, Stephen; Linet, Martha; Wang, Zhaoming; Yeager, Meredith; Wiencke, John K.; Hansen, Helen; Mccoy, Lucie; Rice, Terri; Kosel, Matthew L ...; Sicotte, Hugues; Amos, Christophe ...; Bernstein, Jonin ...; Davis, Faith; Lachance, Dan; Lau, Ching; Merrell, Ryan T.; Shildkraut, Joel ...; Ali-Osman, Franc ...; Sadetzki, Siegal; Scheurer, Michae ...; Shete, Sanjay; Lai, Rose K.; Claus, Elizabeth ...; Olson, Sara H.; Jenkins, Robert ...; Houlston, Richar ...; Bondy, Melissa L ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

Articles in the publication: Nature Genetics

By the university: Umeå University

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