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Genome-wide associa...
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Melin, Beatrice S.Umeå universitet,Institutionen för strålningsvetenskaper
(author)
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2017-03-27
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Springer Science and Business Media LLC,2017
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-135267
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-135267URI
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https://doi.org/10.1038/ng.3823DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 x 10(-9), odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 x 10(-10), OR = 1.24), 16p13.3 (rs2562152; P = 1.93 x 10-8, OR = 1.21), 16q12.1 (rs10852606; P = 1.29 x 10(-11), OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 x 10(-10), OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 x 10(-9), OR = 1.19), 1q44 (rs12076373; P = 2.63 x 10(-10), OR = 1.23), 2q33.3 (rs7572263; P = 2.18 x 10(-10), OR = 1.20), 3p14.1 (rs11706832; P = 7.66 x 10(-9), OR = 1.15), 10q24.33 (rs11598018; P = 3.39 x 10-8, OR = 1.14), 11q21 (rs7107785; P = 3.87 x 10(-10), OR = 1.16), 14q12 (rs10131032; P = 5.07 x 10(-11), OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 x 10(-9), OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Barnholtz-Sloan, Jill S.
(author)
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Wrensch, Margaret R.
(author)
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Johansen, Christoffer
(author)
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Il'yasova, Dora
(author)
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Kinnersley, Ben
(author)
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Ostrom, Quinn T.
(author)
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Labreche, Karim
(author)
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Chen, Yanwen
(author)
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Armstrong, Georgina
(author)
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Liu, Yanhong
(author)
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Eckel-Passow, Jeanette E.
(author)
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Decker, Paul A.
(author)
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Labussiere, Marianne
(author)
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Idbaih, Ahmed
(author)
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Hoang-Xuan, Khe
(author)
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Di Stefano, Anna-Luisa
(author)
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Mokhtari, Karima
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Delattre, Jean-Yves
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Broderick, Peter
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Galan, Pilar
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Gousias, Konstantinos
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Schramm, Johannes
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Schoemaker, Minouk J.
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Fleming, Sarah J.
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Herms, Stefan
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Heilmann, Stefanie
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Noethen, Markus M.
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Wichmann, Heinz-Erich
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Schreiber, Stefan
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Swerdlow, Anthony
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Lathrop, Mark
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Simon, Matthias
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Sanson, Marc
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Andersson, UlrikaUmeå universitet,Institutionen för strålningsvetenskaper(Swepub:umu)ulan0002
(author)
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Rajaraman, Preetha
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Chanock, Stephen
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Linet, Martha
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Wang, Zhaoming
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Yeager, Meredith
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Wiencke, John K.
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Hansen, Helen
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Mccoy, Lucie
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Rice, Terri
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Kosel, Matthew L.
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Sicotte, Hugues
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Amos, Christopher I.
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Bernstein, Jonine L.
(author)
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Davis, Faith
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Lachance, Dan
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Lau, Ching
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Merrell, Ryan T.
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Shildkraut, Joellen
(author)
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Ali-Osman, Francis
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Sadetzki, Siegal
(author)
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Scheurer, Michael
(author)
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Shete, Sanjay
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Lai, Rose K.
(author)
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Claus, Elizabeth B.
(author)
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Olson, Sara H.
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Jenkins, Robert B.
(author)
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Houlston, Richard S.
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Bondy, Melissa L.
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Umeå universitetInstitutionen för strålningsvetenskaper
(creator_code:org_t)
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In:Nature Genetics: Springer Science and Business Media LLC49:5, s. 789-7941061-40361546-1718
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Melin, Beatrice ...
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Barnholtz-Sloan, ...
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Wrensch, Margare ...
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Johansen, Christ ...
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Il'yasova, Dora
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Kinnersley, Ben
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Ostrom, Quinn T.
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Labreche, Karim
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Chen, Yanwen
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Armstrong, Georg ...
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Liu, Yanhong
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Eckel-Passow, Je ...
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Decker, Paul A.
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Labussiere, Mari ...
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Idbaih, Ahmed
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Hoang-Xuan, Khe
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Di Stefano, Anna ...
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Mokhtari, Karima
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Delattre, Jean-Y ...
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Broderick, Peter
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Galan, Pilar
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Gousias, Konstan ...
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Schramm, Johanne ...
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Schoemaker, Mino ...
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Fleming, Sarah J ...
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Herms, Stefan
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Heilmann, Stefan ...
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Noethen, Markus ...
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Wichmann, Heinz- ...
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Schreiber, Stefa ...
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Swerdlow, Anthon ...
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Lathrop, Mark
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Simon, Matthias
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Sanson, Marc
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Andersson, Ulrik ...
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Rajaraman, Preet ...
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Chanock, Stephen
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Linet, Martha
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Wang, Zhaoming
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Yeager, Meredith
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Wiencke, John K.
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Hansen, Helen
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Mccoy, Lucie
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Rice, Terri
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Kosel, Matthew L ...
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Sicotte, Hugues
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Amos, Christophe ...
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Bernstein, Jonin ...
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Davis, Faith
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Lachance, Dan
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Lau, Ching
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Merrell, Ryan T.
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Shildkraut, Joel ...
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Ali-Osman, Franc ...
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Sadetzki, Siegal
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Scheurer, Michae ...
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Shete, Sanjay
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Lai, Rose K.
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Claus, Elizabeth ...
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Olson, Sara H.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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Nature Genetics
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Umeå University